Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-12-17
1993-09-07
Nutter, Nathan M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514453, 514468, 514510, 514691, 514729, 514739, 514766, A01N 4316, A01N 4342, A61K 3147
Patent
active
052429326
ABSTRACT:
Agents which modulate or affect the intracellular trafficking and processing of proteins in the mammalian cell can be utilized to affect the trafficking and processing of APP, thereby inhibiting production of Alzheimer type amyloidosis. Particularly useful agents are chloroquine and its related derivatives such as primaquine.
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Caporaso et al. "Protein phosphorylation regulates secretion of Alzheimer .beta./A4 amyloid precursor protein", Proc. Natl. Acad. Sci., USA vol. 89, pp. 3055-3059, Apr. 1992.
Gandy et al., Alzheimer's Disease: New Therapeutic Approaches, Marcel Dekker, pp. 175-192 (1992), "A Cell Biological Approach to the Therapy of Alzheimer-Type Cerebral .beta./A4-Amyloidosis."
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Caporaso et al., Proc. Natl. Acad. Sci. U.S.A., 89, pp. 2252-2256 (Mar. 15, 1992), "Chloroquine Inhibits Intracellular Degradation But Not Secretion of Alzheimer .beta./A4 Amyloid Precursor Protein."
Cole et al., Neurochemical Research, 14(10), pp. 933-939 (1989), "Evidence for Lysosomal Processing of Amyloid-Protein Precursor in Cultured Cells."
Caporaso Gregg L.
Gandy Samuel E.
Greengard Paul
Nutter Nathan M.
The Rockefeller University
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