Treatment of age related macular degeneration with beta-carotene

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514912, A61K 3107

Patent

active

054571359

ABSTRACT:
According to the present invention, there are provided methods for treating age related macular degeneration in a mammal; for preventing impairment of the vision or for improving impaired vision of a mammal whose eye has drusen; for preventing formation or growth of drusen in the eye of a mammal; and for reducing the number or the size of drusen or for fading drusen without resultant areas of retinal atrophy, without resultant impairment of vision, or without a combination of the foregoing in the eye of a mammal. Beta-carotene in appropriate amounts is administered to the mammal.

REFERENCES:
Federal Research In Progress (1992). Hennkens.
Steven A. Baranowitz, "Regeneration, Neural Crest Derivatives and Retinoids: A New Synthesis," J. Theor. Biol., 140:231-242, 1989.
Garry J. Handelman et al., "Carotenoids in the Human Macula and Whole Retina," Investigative Ophthalmology, 29:850-855, 1988.
Richard W. Young, "Solar Radiation and Age-related Macular Degeneration," Survey of Ophthalmology, 32:252-269, Jan.-Feb., 1988.
Richard W. Young, "Pathophysiology of Age-related Macular Degeneration," Survey of Ophthalmology, 31:291-306, 1987.
Susan B. Bressler et al. "Relationship of Drusen and Abnormalities of the Retinal Pigment Epithelium to the Prognosis of Newvascular Macular Degeneration," Arch Ophthalmol, 108:1442-1447, Oct. 1990.
Neil M. Bressler et al., "Age-related Macular Degeneration," Survey of Ophthalomolgy, 32:375-413, May-Jun., 1988.
Howard Schatz et al., "Atrophic Macular Degeneration Rate of Spread of Geographic Atrophy and Visual Loss," Ophthalmology, 96:1541-1551, 1989.
J. P. Sarks et al., "Evolution of Geographic Atrophy of the Retinal Pigment Epithelium," Eye, 2:552-577, 1988.
D. Pauleikhoff et al., "Drusen as Risk Factors in Age-Related Macular Disease," American Journal of Ophthmology, 109:38-43, Jan. 1990.
W. T. Ham, Jr. et al., "Basic Mechanisms Underlying the Production of Photochemical Lesions in the Mammalian Retina," Current Eye Research, 3:165-174, 1984.
M. L. Katz et al., "Fluorescent Pigment Accumulation in Retinal Pigment Epithelium of Antioxidant-Deficient Rats," Investigative Ophthalmology, 17:1049-1058, 1978.
Martin L. Katz et al., "Relationship Between Dietary Retinol and Lipofuscin in the Retinal Pigment Epithelium," Mechanisms of Ageing and Development, 35:291-305, 1986.
Martin L. Katz et al., "Development of Lipofuscin-Like Fluorescene in the Retinal Pigment Epithelium in Response to Protease Inhibitor Treatment," Mechanisms of Ageing and Development, 49:23-40, 1989.
C. Kathleen Dorey et al., "Cell Loss in the Aging Retina," Investigative Ophthalmology, 30:1691-1699, 1989.
Glenn L. Wing et al., "Topography and Age Relationship of Lipofuscin Concentration in the Retinal Pigment Epithelium," Investigative Ophthalmology, 17, 601-607, 1977.
Sheila K. West et al., "Exposure to Sunlight and Other Risk Factors for Age-Related Macular Degeneration," Arch Ophthalmol, 107:875-879, Jun., 1989.
Mike Boulton et al., "The Formation of Autofluorescent Granules in Cultured Human RPE," Investigative Ophthalmology, 30:82-89, 1989.
Mike Boulton et al., "Age-Related Changes in the Morphology, Absorption and Fluorescence of Melanosomes and Lipofuscin Granules of the Retinal Pigment Epithelium," Vision Research, 30:1291-1303, 1990.
John D. Gottsch et al., "Hematogenous Photosensitization," Investigative Ophthalmology, 31:1674-1683, Sep., 1990.
David A. Newsome et al., "Oral Zinc in Macular Degeneration," Arch Ophthalmol, 106:192-198, Feb., 1988.
Sohrab Mobarhan et al., "Effects of .beta.-Carotene Repletion on .beta.-Carotene Absorption, Lipid Peroxidation, and Neutrophil Superoxide Formation in Young Men," Nutrition & Cancer, 14:195-206, 1990.
Shirley H. Sarks et al., "Age-related Macular Degeneration: Atropic Form," Retina, Chapter 64, 2:149-173, 1989.
Peter A. Campochiaro et al., "Retinoic Acid Promotes Density-Dependent Growth Arrest in Human Retinal Pigment Epithelial Cells," Investigative Ophthmology, 32:65-72, 1991.
R. J. Stephens et al., "Vitamin E Distribution in Ocular Tissues Following Long-Term Dietary Depletion and Supplementation as Determined by Microdissection and Gas Chromatography-Mass Spectrometry," Exp. Eye Research, 47:237-245, 1988.
Craig E. Eldred, "Vitamins A and E in RPE Lipofuscin Formation and Implications For Age-Related Macular Degeneration," Inherited and Environmentally Induced Retinal Degenerations, pp. 113-129, 1989.
John J. Weiter, "Macular Degeneration", Arch. Ophthalmol, 106:183-198, Feb., 1988.
Theo L. van der Schaft, et al., "Is Basal Laminar Deposit Unique for Age-Related Macular Degeneration?" Arch. Ophthalmol, 109:420-425, Mar., 1991.
Health Periodicals Abstract of Western Journal of Medicine, vol. 155, Issue No. 4, Oct. 1991.
Hennkens, Federal Research in Progress (1992) (Research started in 1984).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Treatment of age related macular degeneration with beta-carotene does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Treatment of age related macular degeneration with beta-carotene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of age related macular degeneration with beta-carotene will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2310712

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.