Treatment of adrenocortical hypersecretion and tumor growth

Details Treatment of adrenocortical hypersecretion and tumor growth Treatment of adrenocortical hypersecretion and tumor growth

2006-08-15

2006-08-15

Richter, Johann (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Halogenated hydrocarbon doai

Reexamination Certificate

active

07091248

ABSTRACT:
Chemical substances having selective adrenal toxicity for use in medicine, especially for treatment of adrenocortical hypersecretion and tumour growth. There is provided a compound having the following formula for use in medicine, especially human medicinewhereinthe first phenyl ring comprises one or more substituents R1which is halogen (F, Cl, Br or I), preferably in position 4;R2and R3are halogen,A is a single or double bond between the side chain carbon atoms;the second phenyl ring comprises an electrophilic group R4, preferably in position 3, which is SO2R5or its metabolic precursors S R5and SOR5, NO2or CF3, where R5is H or a lower alkyl, especially CH3;and one or more substituents R6 which is halogen (F, Cl, Br or I), preferably in position 4

REFERENCES:
Lund et al., Novel Involvement of a Mitochondrial Steroid Hydroxylase (P450c11) in Xenobiotic Metabolism, J. Biol. Chem. 1995 270: 20895-20897.
Orjan Lindhe et al.: “Irreversible Binding and Adrenocorticolytic Activity of the DDT Metabolite 3-Methylsulfonyl-DDE Examined in Tissue-Slice Culture”, Environmental Health Perspectives, vol. 109, No. 2, Feb. 2001, pp. 105-110.
C. Johan Jonsson et al.: “Adrenocortical Toxicity of 3-Methylsulphonyl-DDE; 3: Studies in Fetal and Suckling Mice”, Reproductive Toxicology, vol. 6, No. 3, 1992, pp. 233-240.
C.J. Jonsson et al.: “Adrenocortical Toxicity of 3-Methylsulfonyl-DDE in Mice”, Fundamental and Applied Toxicology, vol. 16, 1991, pp. 365-374.
Cecilia Weistrand et al.: “Methylsulfonyl metabolites of PCBs and DDE in human tissues”, STN International, File CAPLUS, CAPLUS accession No. 1997:601115, Document No. 127:273940, Environ. Health Perspect. (1997), 105(6), 644-649.
Ya. G. Bal'on et al.: Synthesis of nitro- and amino-derivatives of 1,1,1-trichloro-2-(2'-chlorophyenyl)-2-(4'-chlorophenyl)ethane (2,4-DDT) and 1,1-dichloro-2-(2'-chlorophenyl)-2-(4'-chlorophenyl)ethane (2,4'-DDD), STN International, File CAPLUS, CAPLUS accession No. 1992:235159, Document No. 116:235159, Ukr. Khim. Zh. (Russ. Ed.) (1991), 57(8), 886-8.
Koichi Haraguchi et al.: “PCB methyl sulphone. Comparison of tissue levels in baltic grey seals and a Yusho patient”, STN International, File CAPLUS, CAPLUS accession No. 1991:600483, Document No. 115:200483, Fukuoka Igaku Zasshi (1991), 82(5), 269-73.
A. William McBlain et al.: “Resolution of the optical isomers of o,p'-DDT”, STN International, File CA, Chemical abstracts, accession No. 84:89720, Tetrahedron Lett. (1975), (49), 4351-2.
Wooten et al., “Adrenal Cortical Carcinoma, Epidemiology and Treatment with Mitotane and a Review of the Literature”, CANCER, Dec. 1, 1993, vol. 72, No. 11, pp. 3145-3155.
Jonsson et al., “In vitro bioactivation of the environmental pollutant 3-methylsulphonyl-2,2-bis(4-chlorophenyl)-1, 1-dichloroethene in the human adrenal gland”, Toxicology Letters 71, 1994, pp. 169-175.
Johansson et al., “Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line”, Toxicology in Vitro 16, 2002, pp. 113-121.

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