Treatment of adenovical infections with 3'-fluoro-5-halo uracil

Details Treatment of adenovical infections with 3'-fluoro-5-halo uracil Treatment of adenovical infections with 3'-fluoro-5-halo uracil

1992-12-24

1994-12-27

Hollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 49, 514912, 536 282, 536 2853, 536 2855, A61K 3170

Patent

active

053766440

ABSTRACT:
2',3'-Dideoxy-3'-fluoro pyrimidine nucleosides particularly 2', 3'-dideoxy-3'-fluorothymidine have been found to have particularly potent activity against adenovirus infections especially those caused by adenoviruses of scrotype 8. Such compounds are preferably presented in pharmaceutical formulations adapted for ophthalmic administration.

REFERENCES:
patent: 3775397 (1973-11-01), Etzold et al.
patent: 5070078 (1991-12-01), Selway et al.
Herdewijn et al., Journal of Medicinal Chemistry, vol. 30, No. 8, pp. 1270-1278, (1987).
Ajmera et al., Journal of Medicinal Chemistry, vol. 27, No. 1, pp. 11-14, (1984).
Krenitsky et al., Journal of Medicinal Chemistry, vol. 26, No. 6, pp. 891-895, (1983).
Beres et al., Journal of Medicinal Chemistry, vol. 29, No. 4, pp. 494-499, (1986).

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