Treatment of acute coronary syndrome with GLP-1

Details Treatment of acute coronary syndrome with GLP-1 Treatment of acute coronary syndrome with GLP-1

2006-06-06

2006-06-06

Wax, Robert A. (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C424S542000, C530S324000

Reexamination Certificate

active

07056887

ABSTRACT:
The invention relates to methods for treating a patient suffering from acute coronary syndrome, but who is not suffering from a Q-wave myocardial infarction, comprising administration of a therapeutically effective amount of an exendin-4 molecule. The exendin-4 can be self-administered, and can be administered in one or more doses, as needed, on an intermittent or continuous basis, to optimize metabolism in cardiac tissue and to prevent cardiac damage associated with ischemia.

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Nikolaidis et al., “GLP-1 Improves Myocardial Performance in Conscious Dogs with Pacing Induced Heart Failure,” Journal of the American College of Cardiology, vol. 37, No. 2 Supplement A, 50thAnnual Scientific Session of the American College of Cardiology, Orlando, Florida, USA, Mar. 18, 2001, 1 sheet.

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