Treatment of actinic keratoses with calcium channel blockers

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing

Reexamination Certificate

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Details

C514S211090, C514S649000, C514S277000

Reexamination Certificate

active

07851431

ABSTRACT:
The present invention relates to methods and compositions for the treatment and/or prevention of actinic keratoses comprising a calcium channel blocking compound.

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Mauro et al., Keratinocyte K+ Channels Mediate Ca2+-Induced Differentiation, 1997, The Society for Investigative Dermatology, Inc., 108 (6), 864-870.
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Fitscha et al., “The Diminished Extracellular Matrix Production Induced by Isradipine, a Calcium Channel Blocker, is Completely Abolished by Cyclooxygenase Inhibition,”Prost. Leukot. Essent. Fatty Acids, 45:289-291, 1992.
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Lober and Fenske, “Optimum treatment strategies for actinic keratosis (intraepidermal squamous cell carcinoma),”Am. J. Clin. Dermatol., 5:395-401, 2004.
Rodler et al., “Ca(2+)-channel blockers modulate the expression of interleukin-6 and interleukin-8 genes in human vascular smooth muscle cells,”J. Mol. Cell Cardiol., 27:2295-2302, 1995.
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