Treatment of a hemoglobinopathy

Details Treatment of a hemoglobinopathy Treatment of a hemoglobinopathy

1997-04-04

1999-03-23

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Nitrates or nitrites or nitric acid or nitrogen oxides

514624, 514815, A61K 31165, A61K 3300

Patent

active

058856218

ABSTRACT:
Disclosed are methods for treating a patient identified as having a hemoglobinopathy that is characterized by a reduced affinity of hemoglobin for oxygen. The methods involve providing gaseous nitric oxide and/or carbon monoxide for (i) inhalation by the patient or (ii) ex vivo treatment of the patient's erythrocytes. Alternatively, a nitric-oxide-releasing compound can be administered to the patient.

REFERENCES:
patent: 4954526 (1990-09-01), Keefer
patent: 5155137 (1992-10-01), Keefer et al.
patent: 5380945 (1995-01-01), Murad et al.
C.D.R. Borland et al., A Comparison Of The Rate Of Reaction Of Nitric Oxide (No) With Human Whole Blood And Plasma: Gaseous No Reacts More Rapidly With Red Cells Than Plasma, p. A792, (1989).
BT Catalyst, Duke Research Piques Apex's Interest; May Yield Collaboration, May 1996, Biotechnology Center vol. 10, No. 4, pp. 1-2.
Gustave Freeman, M.D. et al., Identification Of Nitric Oxide (NO) In Human Blood, Jan./Feb. 1978, Archives of Environmental Health, pp. 19-23.
Barbara S. Shapiro et al., The Acute Painful Episode, (1994) Sickle Cell Disease: Basic Principles and Clinical Practice, 35:531-543.
J.M. Salhany et al., Correlation between Quaternary Structure and Ligand Dissociation Kinetics for Fully Liganded Hemoglobin, (1975) Biochemistry, vol. 14, No. 10, pp. 2180-2190.
Calogero Messana et al., Influence of Quaternary Structure of the Globin on Thermal Spin Equilibria in Different Methemoglobin Derivatives, (1978) Biochemistry, vol. 17, No. 17, pp. 3652-3662.
Robert C. Darling et al., The Effect of Methemoglobin on the Equilibrium Between Oxygen and Hemoglobin, (1942) The American Journal of Physiology, vol. 137 pp. 56-68.
Helen R. Sunshine et al., Requirements for therapeutic inhibition of sickle haemoglobin gelation, Sep. 21, 1978, Nature, vol. 275 pp. 238-240.
Walter S. Root, Carbon Monoxide, Handbook of Physiology--Respiration II, 43:1087-1098, (1943).
F.J.W. Roughton et al., The Effect of Carbon Monoxide on the Oxyhemoglobin Dissociation Curve, Oct. 29, 1943 from the Fatigue Laboratory, Harvard University, Boston, Mass, pp. 17-31.
Li Jia, et al., S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control, Mar. 21, 1996, Nature, vol. 380, pp. 221-226.
Sandra Blakeslee, Study Finds Major New Task Of Hemoglobin in the Blood, Mar. 21, 1996, The New York Times continued on p. A22, col. 3.
Mark A. Goldberg, M.D., et al., Treatment of Sickle Cell Anemia with Hydroxyurea and Erythropoietin, Aug. 9, 1990, New England Journal of Medicine, 323:336-372.
Samuel Charache, M.D., et al., Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia May 18, 1995, New England Journal of Medicine, vol. 332 No. 20, pp. 1317-1322.
Thomas R. Kinney et al., Compound Heterozygous States, (1994) Sickle Cell Disease: Basic Principles and Clinical Practice, 29:437-451.
Louis Ignarro et al., Nitric Oxide, Biochemistry, Molecular Biology, and Therapeutic Implications, (1995) Advances in Pharmacology, vol. 34, p. 387.
Teddy G. Traylor et al., Why No?, Mar. 24, 1992, Biochemistry, vol. 31, No. 11, pp. 2847-2849.
Robert C. Griggs, M.D. et al., The Biophysics of the Variants of Sickle-Cell Disease, Sep. 30, 1955 A.M.A. Archives of Internal Medicine, pp., 315-326.
Robin W. Briehl et al., Gelation of Sickle Cell Haemoglobin, II Methaemoglobin, (1974) J. Mol. Biol. 89:759-766.
L. Jia, et al., No hypertension?, Mar. 21, 1996, Nature, 1 page.
Eraldo Antonini et al., Preparation and Kinetic Properties of Intermediates in the Reaction of Hemoglobin and Ligands, Mar. 15, 1996, Squalene Biosynthesis, vol. 241, No. 13, pp. 3236-3238.
Edwin G. Moore et al., Cooperativity in the Dissociation of Nitric Oxide from Hemolobin, May 10, 1976 The Journal of Biological Chemistry, vol. 251, No. 9, pp. 2788-2794.
Q.H. Gibson, The Kinetics and Equilibria of the Reactions of Nitric Oxide with Sheep Haemoglobin, (1957) 136:507-526.
Michael P. Doyle et al., Oxidation of Nitrogen Oxides by Bound Dioxygen in Hemoproteins, (1981) Journal of Inorganic Biochemistry 14:351-358.
C. Toothill, The Chemistry of the In Vivo Reaction Between Haemoglobin and Various Oxides of Nitrogen, (1967) Brit. F. Anaesth., 39:405-412.
Robin W. Briehl et al., Gelation of Sickle Hemoglobin, III. Nitrosyl Hemoglobin, (1975) J. Mol. Biol. 96:733-743.
Benjamin Gaston et al., Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways, Dec. 1993, Proc. Natl. Acad. Sci. USA, vol. 90, No. 23, pp. 10957-10961.
Hajime Oda, M.D. et al., Nitrosyl-Hemoglobin Formation in the Blood of Animals Exposed to Nitric Oxide Sep. 1975, Arch. Eviron. Health, vol. 30, pp. 453-456.
Mitsuaki Moriguchi et al., Nitric Oxide Can Modify Amino Acid Residues in Proteins, Mar. 16, 1992 Biochemical and Biophysical Research Communications, vol. 183, No. 2, pp. 598-604.
Kazunori Kon et al., Effect of Nitric Oxide on the Oxygen Transport of Human Erythrocytes, (1977) Journal of Toxicology and Environmental Health, 2:1109-1113.
Vijay S. Sharma et al., Reaction of Nitric Oxide with Heme Proteins and Model Compounds of Hemoglobin, (1987) Biochemistry, 26:3837-3843.
Ernest Beutler et al., The Effect of Methemoglobin Formation in Sickle Cell Disease, (1961), J. Clin. Invest. 40:1856-1871.

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