Treatment method of bone and osteoblasts with neurotrophin-3 (NT

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 2, A61K 3818

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active

060807202

ABSTRACT:
This invention relates to a composition for metabolic bone diseaese and/or bone fractures which comprises a pharmaceutically acceptable carrier and human neurotrophin-3 (NT-3).
This invention also relates to a method for the treatment and/or prevention of metabolic bone diseaese or bone fractures which comprises administering to a patient in need of said treatment and/or prevention a medicament containing an effective amount of human neurotrophin-3 (NT-3).

REFERENCES:
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Merck Manual, 16.sup.th Edition, Robert Berkow(ed.), Merck Research Laboratories, Rahway, N.J., 1992, pp. 1359-1360.
Kalcheim et al., "Neurotrophin 3 is a Mitogen for Cultured Neural Crest Cells," Proc. Natl. Acad. Sci. USA 89:1661-65 (1992).
Snider, W., "Functions of the Neurotrophins During Nervous System Development: What the Knockouts are Teaching Us," Cell 77:627-38 (1994).
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