Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1995-06-02
1998-05-05
Reamer, James H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
5142392, 514255, A61K 31135
Patent
active
057475431
ABSTRACT:
The in vivo chemotherapeutic treatment of cancer cells in a living animal is improved by first administering to the animal, a compound which inhibits normal cell proliferation while promoting malignant cell proliferation, specifically a potent antagonist selective for intracellular histamine receptors, in an amount sufficient to inhibit the binding of intracellular histamine to the receptors in normal and malignant cells. An enhanced toxic effect on the cancer cells from the chemotherapeutic agent is obtained while any adverse effect of the chemotherapeutic agent on normal cells, particularly bone marrow and gastro-intestinal cells, is inhibited. In addition, long term continuous administration of the antagonist following administration of the chemotherapeutic agent results in at least amelioration of adverse side effects of chemotherapy on normal bone marrow and gastro-intestinal cells. The treatment of cancer cells using DPPE in combination with the chemotherapeutic agents specifically illustrates the invention.
REFERENCES:
patent: 4803227 (1989-02-01), Brandes et al.
patent: 4829068 (1989-05-01), Brandes et al.
Anticancer Research 6:451 to 464 (1986), Robert C. Warrington;.
Histamine is an Intracellular Messenger Mediating Platelet Aggregation by Saxena et al, Science, vol. 243; pp. 1596-1599;.
The Merck Index, 9th Edition, Merck & Co., Inc. Rahway, N.J., U.S.A., 1976 p. 456 (WO3428).
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