Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2007-08-28
2007-08-28
Angell, Jon Eric (Department: 1635)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C424S093100
Reexamination Certificate
active
10143536
ABSTRACT:
It has been discovered that increasing telomerase activity in cells surrounding a wound has a variety of effects that enhance wound healing. Replication capacity is enhanced, and the mobility of the epithelial cells can be increased by 3-fold or more. Some aspects of the invention relate to agents that increase telomerase activity in cells at the site of the wound, promoting cells to move to the site and restore an epithelial layer and the underlying stratum. Other aspects of the invention relate to compositions comprising epithelial cells in which telomerase activity has been increased, useful as grafts for the treatment of wounds.
REFERENCES:
patent: 4016036 (1977-04-01), Green et al.
patent: 4304866 (1981-12-01), Green et al.
patent: 4745098 (1988-05-01), Michaeli
patent: 4837024 (1989-06-01), Michaeli
patent: 5556620 (1996-09-01), Ralph et al.
patent: 5561107 (1996-10-01), Jaynes et al.
patent: 5580781 (1996-12-01), Naughton et al.
patent: 5583016 (1996-12-01), Villeponteau et al.
patent: 5641670 (1997-06-01), Treco et al.
patent: 5698436 (1997-12-01), Morgan et al.
patent: 5718897 (1998-02-01), Herman
patent: 5720981 (1998-02-01), Eisinger
patent: 5733761 (1998-03-01), Treco et al.
patent: 5824647 (1998-10-01), Postlethwaite et al.
patent: 5861153 (1999-01-01), Schmidt et al.
patent: 5965530 (1999-10-01), Pierce et al.
patent: 5980888 (1999-11-01), Dimoudis et al.
patent: 5997863 (1999-12-01), Zimmermann et al.
patent: 6025150 (2000-02-01), Livant
patent: 6077602 (2000-06-01), Liestman et al.
patent: 6110208 (2000-08-01), Soranzo et al.
patent: 6166178 (2000-12-01), Cech et al.
patent: 6191110 (2001-02-01), Jaynes et al.
patent: 6261556 (2001-07-01), Weinrich et al.
patent: 6261836 (2001-07-01), Cech et al.
patent: 6617110 (2003-09-01), Cech et al.
patent: WO97/08295 (1997-03-01), None
patent: WO97/23602 (1997-07-01), None
patent: WO99/27113 (1999-06-01), None
patent: WO99/47644 (1999-09-01), None
patent: WO99/54435 (1999-10-01), None
patent: WO 00/31238 (2000-06-01), None
patent: WO 00/47148 (2000-08-01), None
Bodnar, et al., Extension of life-span by introduction of telomerase into normal human cells, Science 279:349 (1998).
Campisi, et al., The role of cellular senescence in skin aging, J Investig Dermatol Symp Proc. 3:1 (1998).
Deveci, M., Telomeres and telomerase and their possible future in plastic surgery, Plast. Reconstr. Surg. 104:1588 (1999).
Dickson, et al., Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation charachteristics, Mol. Cell. Biol. 20:1436 (2000).
Driscoll, et al., Telomerase in alveolar epithelial development and repair, Am J. Physiol. Lung. Cell. Mol. Physiol. 279:L1191 (2000).
Farwell, et al., Genetic and epigenetic changes in human epithelial cells immortalized by telomerase, Am. J. Pathol. 156:1537 (2000).
Fujimoto, et al., Expression of telomerase components in oral keratinocytes and squamous cell carcinomas, Oral. Oncol. 37:132 (2001).
Funk, et al., Telomerase expression restores dermal integrity to in vitro-aged fibroblasts in a reconstituted skin model, Exp. Cell Res. 258:270 (2000).
Gonzalez-Suarez, et al., Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes, EMBO J 20:2619 (2001).
Harle-Bachor, et al., Telomerase activity in the regenerative basal layer of the epidermis in human skin and in immortal and carcinoma-derived skin keratinocytes, Proc. Natl. Acad. Sci. USA 93:6476 (1996).
Holmberg, et al., Ester synthesis with dicyclohexylcarbodiimide improved by acid catalysts, Acta Chemica Scandinavica B 33:410 (1979).
Jiang, et al., Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype, Nat. Genet. 21:111 (1999).
Kang, et al., Replicative senescence of normal human oral keratinocytes is associated with the loss of telomerase activity without shortening of telomeres, Cell Growth Differ. 9:85 (1998).
Kiyono, et al., Both Rb/p16INK4ainactivation and telomerase activity are required to immortalize human epithelial cells, Nature 396:84 (1998).
LaFrance, et al., Novel living skin replacement biotherapy approach for wounded skin tissues, Tissue Eng 5:153 (1999).
Li, et al., Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype, Proc Natl Acad Sci USA 95:3902 (1998).
Martin, Wound healing—aiming for perfect skin regeneration, Science 276:75 (1997).
Mattson, et al., Emerging roles for telomerase in neuronal development and apoptosis, J. Neurosci Res 63:1 (2001).
Matsui, et al., Influence of aging and cell senescence on telomerase activity in keratinocytes, J. Dermatol. Sci. 22:80 (2000).
Mendez, et al., Fibroblasts cultured from venous ulcers display cellular characteristics of senescence, J. Vasc. Surg. 28:876 (1998).
Morales, et al., Lack of cancer-associated changes in human fibroblasts after immortalization with telomerase, Nature Genet. 21:115 (1999).
Nakamura, et al., Telomerase Catalytic Subunit Homologs from Fission Yeast and Human, Science 277:955 (1997).
Ogoshi, et al., In situ hybridization analysis of the expression of human telomerase RNA in normal and pathologic conditions of the skin, J. Invest. Dermatol. 110:818 (1998).
Osanai, et al., Transcient increase in telomerase activity of proliferating fibroblasts and endothelial cells in granulation tissue of the human skin, Wound Repair Regen. 10:59 (2002).
Ramirez, et al., Telomerase activity concentrates in the mitotically active segments of human hair follicles, J. Invest. Dermatol. 108:113 (1997).
Ramirez, et al., Progressive Increase in Telomerase Activity From Benign Melanocytic Conditions to Malignant Melanoma, Neoplasia 1:00 (1999).
Ramirez, et al., Putative telomere-indepentant mechanisms of replicative aging reflect inadequate growth conditions, Genes & Dev. 15:398 (2001).
Rambatla, et al., In vitro differentiation capacity of telomerase immortalized human RPE cells, invest Ophthalmol. Vis. Sci. 43:1622 (2002).
Rudolph, et al., Longevity, stress response, and cancer in aging telomerase-deficient mice, Cell 96:701 (1999).
Taylor, et al., Detection of Telomerase Activtion in Malignant and Nonmalignant Skin Conditions, J. Invest. Dermatol. 106:759 (1996).
Ueda, et al., Evidence for UV-associated Activation of Telomerase in Human Skin, Cancer Research 57:370 (1999).
Voigt, et al., Cultured epidermal keratinocytes on a microspherical transport system are feasible to reconstitute the epidermis in full-thickness wounds, Tissue Eng. 5:563 (1999).
Wang, et al., Risky immortalization by telomerase, Nature 405:755 (2000).
Yang, et al., Human endothelial cell life-extension by telomerase expression, J. Biol. Chem. 274:26141 (1999).
Yang, et al., Telomerized human microvasculature is functional in vivo, Nat. Biotechnol. 19:219 (2001).
Zhao, P., et al., Telomerase activity in radiation-induced chronic human skin ulcers, J. Environ. Pathol. Toxicol. Oncol. 18:17 (1999).
Zhou, et al., Expression of telomerase reverse transcriptase in radiation-induced chronic human skin ulcer, J. Environ. Pathol. Toxicol. Oncol. 21:67 (2002).
Chiu Choy-Pik
Harley Calvin B.
Jiang Xu-Rong
Angell Jon Eric
Geron Corporation
LandOfFree
Treatment for wounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Treatment for wounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment for wounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3866877