Treatment for the inhibition of neuro-degenerative disease state

Details Treatment for the inhibition of neuro-degenerative disease state Treatment for the inhibition of neuro-degenerative disease state

1996-05-06

1998-03-24

MacMillan, Keith

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ether doai

A61K 3108

Patent

active

057313547

ABSTRACT:
A method of inhibiting degeneration of neural cells comprising treating the cells with an effective degeneration-inhibiting amount of one or more compounds of Formula I: ##STR1## wherein R is a C.sub.12 to C.sub.22 linear or branched alkyl group, or pharmaceutically-acceptable salts thereof is disclosed.

REFERENCES:
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Horrocks (1972); in "Ether Lipids: Chemistry and Biology," Snyder, F. Ed., pp. 177-272.
Nunez and Clarke (1994); "The Bcl-2 Family of Proteins: Regulators of Cell Death and Survival," Trends in Cell Biology, 4:399-403.
Paltauf, F. (1994); "Ether lipids in biomembranes," Chemistry and Physics of Lipids, 74:101-139.
Reder, A. T.; Thapar, M.; Sapugay, A.M.; Jensen, M.A. (1994); Journal of Neuroimmunology, 54:117-127.
Reiter (1995); "Oxidative Processes and Antioxidative Defense Mechanisms in the Aging Brain," FASEB, 9:526-533.
Selmaj, K.; Papierz, W.; Glabinski, A.; Kohno, T. (1995); Journal of Neuroimmunology, 56:135-141.
Wanders et al. (1986); J. Inher. Metab. Dis., 9:335-342.
Zoeller et al., A Possible Role for Plasmalogens in Protecting Animal Cells against Photsensitized Killing (1988), The Journal of Biological Chemistry, vol. 263, No. 23, pp. 11590-11596.

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