Treatment for osteoporosis using hGRF(1-40)NH.sub.2

Details Treatment for osteoporosis using hGRF(1-40)NH.sub.2 Treatment for osteoporosis using hGRF(1-40)NH.sub.2

1985-09-27

1987-12-01

Brown, J. R.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

514 2, A61K 3702, A61K 3555

Patent

active

047103825

ABSTRACT:
A method of treating osteoporosis, especially postmenopausal osteoporosis, by administering on a periodic but regular basis to a patient growth hormone releasing factor, GRF(1-44)--NH.sub.2, or a biologically active analog thereof, and continuing the administration until bone mass increases and the patient's calcium balance becomes positive and indicates a mineral accumulation in the skeleton.

REFERENCES:
patent: 4529595 (1985-07-01), Rivier et al.
Lance et al., Biochemical and Biophysical Research Communications, 119, No. 1, 265-271 (1984).
Rivier et al., 8th American Peptide Symposium, Tucson, Ariz., May 22-27, p. 237, 1983.
Heaney et al., Dept. of Med., Creighton University, Omaha, Neb., 1971, GHi The Effect on Skeletal Renwal in Adult Dogs.
Harris, Nature, 223, No. 5204, 403-405 (1969), Effect of GH on Skeletal Mass in Adult Dogs.
Johnson, Indiana Univ. Med. Center, Indianapolis, 1979, Guidlines for Clinical Evaluation of Drugs used in the Treatment of Osteoporosis.
Bogers et al, Journal of Clinical Endrocrinology and Metab., vol. 59, No. 1 (1984) pp. 1-6.
Schriock, et al, Journal of Clinical Endrocrinology and Metab., vol. 58, No. 6 (1984) pp. 1043-1048.
Science, vol. 218, Nov. 5, 1982 pp. 585-587.
Rivier et al, Nature, vol. 300, Nov. 18, 1982, pp. 276-278.

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