Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1991-04-24
1993-08-17
Wityshyn, Michael G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, A61K 3702
Patent
active
052369013
ABSTRACT:
The present invention relates to a method of treatment of functional bowel disease in mammals. More specifically, this invention contemplates prophylaxis and treatment of functional bowel disease in mammals by the administration of antagonists of corticotropin releasing factor. The present invention also relates to pharmaceutical compositions of these antagonists useful in the treatment of functional bowel disease in mammals.
REFERENCES:
Bost, et al. (1985) "Similarity Between the Cortictropin (ACTH) Receptor and a Peptide Encoded by an RNA that is Complementary to ACTH mRNA", Proc. Natl. Acad. Sci., USA, 82, 1372-1375.
Narducci, et al. (1985) "Increased Colonic Motility During Exposure to a Stressful Situation", Digestive Diseases and Science, 30, 40-44.
Rivier, et al. (1985) "Synthetic Competitive Antagonists of Corticotropin-Releasing Factor: Effect of ACTH Secretion in Rat", Science, 224, 889-891.
Rivier, et al. (1985) "Involvement of Corticptropin-Releasing Factor and Somatostatin in Stress-Induced Inhibition of Growth Hormone Secretion in the Rat", Endocrinology, 117, 2478-2482.
Williams, et al. (1986) "Cold Water Swim Stress Inhibits Small Intestinal Transit in Rats: No Apparent Opioid or Adrenergic Mediation", Gastroenterology, 90, 1800.
Burks Thomas F.
Williams Cynthia A.
Koh Choon P.
Research Corporation Technologies Inc.
Wityshyn Michael G.
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