Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Patent
1995-05-22
1999-03-30
Feisee, Lila
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
4241331, 4241451, 4241521, 4241581, 4241721, 514 2, A61K 39395, A01N 3718
Patent
active
058885072
ABSTRACT:
A method for the prevention of insulin dependent (type I) diabetes. The method comprises administration of an antibody, polypeptide or other molecule recognizing VLA-4.
REFERENCES:
patent: 4833092 (1989-05-01), Geysen
patent: 4879313 (1989-11-01), Tjoeng et al.
patent: 4952562 (1990-08-01), Klein et al.
patent: 5053392 (1991-10-01), Klein et al.
patent: 5053393 (1991-10-01), Klein et al.
patent: 5061693 (1991-10-01), Nutt et al.
Jakobowski et al, J. Immunol, 1995, 155:938-946.
Osband et al, Immunol Today, 11:193-195, 1990.
Barlow and Like (1992) "Anti-CD2 Monoclonal Antibodies Prevent Spontaneous and Adoptive Transfer of Diabetes in the BB/Wor Rat" Amer. J. Pathol. 141: 1043-1051.
Baron et al. (1993) "Surface Expression of .alpha.4 Integrin by CD4 T Cells is Required for Their Entry into Brian Parenchyma" J. Exp. Med 177: 57-68.
Barton et al. (1989) "The Effect of Anti-Intercellular Adhesion Molecule-1 on Phorbolester-Induced Rabbit Lung Inflammation" J. Immunol. 143: 1278-1282.
Boerner et al. (1991) "Production of Antigen-Specific Human Monoclonal Antibodies from In Vitro-Primed Human Splenocytes" J. Immunol. 147: 86-95.
Burkly et al. (1991) "Signaling by Vascular Cell Adhesion Molecule-1 (VCAM-1) Through VLA4 Promotes CD3-Dependent T Cell Proliferation" Eur. J. Immunol. 21: 2871-2875.
Carlos et al. (1990) "Vascular Cell Adhesion Molecule-1 Mediates Lymphocyte Adherence to Cytokine-Activated Cultured Hman Endothelial Cells" Blood 17(5): 965-970.
Castano and Eisenbarth (1990) "Type I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat" Annu. Rev. Immunology 8: 647-679.
Devlin et al. (1990) "Random Peptide Libraries: A Source of Specific Protein Binding Molecules" Science 249: 404-406.
Dosquet et al. (1992) "Molecular mechanism of blood monocyte adhesion to vascular endothelial cells" Nouvelle Revue Fran.cedilla.aise D'Hematologie 34(Suppl.): S55-S59.
Dustin et al. (1986) "Induction by IL-1 and Interferon-.gamma. Tissue Distribution, Biochemistry, and Function of a Natural Adherence Molecule (ICAM-1)" J. Immunol. 137: 245-254.
Eisenbarth (1987) "Type I Diabetes: Clinical Implication of Autoimmunity" Hosp. Prac. 22: 167-184.
Eisenbarth (1986) "Type I Diabetes Mellitus--A Chronic Autoimmune Disease" New Engl. J. Med. 314: 1360-1368.
Elices et al. (1990) "VCAM-1 on Activated Endothelium Interacts with the Leukocyte Integrin VLA4 at a Site Distinct from the VLA4/Fibronectin Binding Site" Cell 60: 577-584.
Federlin and Becker (1990) "Specific Therapeutic Attempts in Experimental and Clinical Type-I Diabetes" Klin. Wochenschr. 68: (Suppl. XXI) 38-43.
Foulis et al. (1986) "The Histopathology of the Pancreas in Type I (Insulin-Dependent) Diabetes Mellitus: A 25-Year Review of Deaths in Patients Under 20 Years of Age in the United Kingdom" Diabetologia 29: 267-274.
Fujita et al. (1982) "Lymphocytic Insulitis in a `Non-obese Diabetic (NOD)` Strain of Mice: An Immunohistochemical and Electron Microscope Investigation" Biomed. Res. 3: 429-443.
Harada and Makino (1986) "Suppression of Overt Diabetes in NOD Mice by Anti-Thymocyte Serum or Anti-Thy 1.2 Antibody" Exp. Anim. 35: 501-504.
Harding et al. (1992) "CD28-Mediates Signalling Co-Stimulates Murine T Cells and Prevents Induction of Energy in T Cell Clones" Nature 356: 607-609.
Harris and Emery (1993) "Therapeutic Antibodies--The Coming of Age" Tib. Tech. 11: 42-44.
Hemler et al. (1987) "Characterization of the Cell Surface Heterodimer VLA4 and Related Peptides" J. Biol. Chem. 262: 11478-11485.
Hemler et al. (1990) "Structure of the Integrin VLA-4 and its Cell-Cell and Cell-matrix Adhesion Functions" Immunol. Rev. 114: 45-65.
Hession et al. (1992) "Cloning of Murine and Rat Vascular Cell Adhesion Molecule-1" Biochem. Biophys. Res. Commun. 183: 163-169.
Holzmann et al. (1989) "Identification of a Murine Peyer's Patch-Specific Lymphocyte Homing Receptor as an Integrin Molecule with a Chain Homologous to Human VLA-4.alpha." Cell 56: 37-46.
Hooks et al. (1991) "Muromonab CD-3: A Review of Its Pharmacology, Pharmacokinetics, and Clinical Use in Transplantation" Pharmacology 11(1) 26-37.
Huang and Stollar (1991) "Construction of Representative Immunoglobin Variable Region cDNA Libraries from Human Peripheral Blood Lymphocytes Without In Vitro Stimulation" J. Immunol. Methods 141: 227-236.
Hutchings et al. "Transfer of Diabetes in Mice Prevented by Blockade of Adhesion-promoting Receptor on Macrophages" Nature 348: 639-642.
Issekutz (1991) "Inhibition of In Vivo Lymphocyte Migration to Inflammation and Homing to Lymphoid Tissues by the TA-2 Monoclonal Antibody--A Likely Role for VLA-4 in Vivo" J. Immunol 147: 4178-4184.
Issekutz and Issekutz (1991) "T Lymphocyte Migration to Arthritis Joints and Dermal Inflammation in the Rat: Differing Migration Patterns and the Involvement of VLA-4" Clinical Immunol. and Immunopathol. 61: 436-447.
Jones et al. (1986) "Replacing the Complementarity-Determining Regions in a Human Antibody with Those from a Mouse" Nature 321: 522-525.
Kirkham et al. (1992) "Chimeric CD7 Monoclonal Antibody Therapy in Rheumatoid Arthritis" J. Rheum. 19(9); 1348-1352.
Knox et al. (1991) "Observations on the Effect of Chimeric Anti-CD4 Monoclonal Antibody in Patients with Mycosis Fungoides" Blood 77(1): 20-30.
Kohler and Milstein (1975) "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity" Nature 265: 495-497.
Koike et al. (1987) "Preventive Effect of Monoclonal Anti-L3T4 Antibody on Development of Diabetes in NOD Mice" Diabetes 36: 539-541.
Larson and Springer (1990) "Structure and Funtion of Leukocyte Integrins" Immunol. Rev. 114: 181-217.
Like et al. (1986) "Prevention of Diabetes in Biobreeding/Worchester Rats with Monoclonal Antibodies that Recognize T Lymphocytes or Natural Killer Cells" J. Exp. Med. 164: 1145-1159.
Lobb (1992) "Integrin-Immunoglobulin Superfamily Interactions in Endothelial-Leukocyte Adhesion" in Adhesion: Its Role in Inflammatory Disease (J.M. Harlan and D.Y. Liu, eds., New York: W. H. Freeman) 1-18.
Makino et al. (1986) "Absence of Insulitis and Overt Diabetes in Athymic Nude Mice with NOD Genetic Background" Exp. Anim. 35: 495-498.
Miller, B. et al. (1993) "Specific Interaction of Lymphocyte Function-associated Antigen 3 with CD2 Can Inhibit T Cell Responses" J. Exp. Med. 178: 211-222.
Miller, G. et al. (1988) "Both the Lyt-2.sup.+ and L3T4.sup.+ T Cell Subsets are Required for the Transfer of Diabetes in Nonobese Diabetic Mice" J. Immunol. 140: 52-58.
Miyake et al. (1991) "Evidence for a role of the integrin VLA-4 in Lympho-hemopoiesis" J. Exp. Med. 173: 599-607.
Moingeon et al. (1989) "The Structural Biology of CD2" Immunol. Rev. 111: 111-144.
Moreland et al. (1993) "Use of a Chimeric Monoclonal Anti-CD4 Antibody in Patients with Refractory Rheumatoid Arthritis" Arthritis and Rheumatism 36(3): 307-318.
Nomikos et al. (1986) "Combined Treatment with Nicotinamide and Desferrioxamine Prevents Islet Allograft Destruction in NOD Mice" Diabetes 35: 11302-11304.
Orlandi et al. "Cloning Immunoglobulin Variable Domains for Expression by the Polymerase Chain Reaction" Proc. Natl. Acad. Sci. USA 86: 3833-3837.
Osborn (1990) "Leukocyte Adhesion to Endothelium in Inflammation" Cell 62: 3-6.
Osborn et al. (1989) "Direct Expression Cloning of Vascular Cell Adhesion Molecule 1, a Cytokine-Induced Endothelial Protein That Binds to Lymphocytes" Cell 59: 1203-1211.
Persson et al. (1991) "Generation of Diverse High-Affinity Human Monoclonal Antibodies by Repertoire Cloning" Proc. Natl. Acad. Sci USA 88: 2432-2436.
Pulido et al. (1991) "Functional Evidence for Three Distinct and Independently Inhibitable Adhesion Activities Mediated by the Human Integrin VLA-4" J. Biol. Chem. 266(16): 10241-10245.
Queen et al. "A Humanized Antibody that Binds to the Interleukin 2 Receptor" Proc. Natl. Acad. Sci USA 86: 10029-10033.
Rice et al. (1990) "Inducible Cell Adhesion Molecule 110 (NCAM-110) Is An Endothelial Receptor for Lymphocytes--A CD11/CD18-Independent Adhesion Mechanism" J. Exp. Med. 171: 1369-1374.
Rice et al. (1991) "Vascular Nonvascular Expression of INCAM-110" J. Am. J. Path. 138:
Biogen Inc.
Feisee Lila
Ungar Susan
LandOfFree
Treatment for insulin dependent diabetes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Treatment for insulin dependent diabetes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment for insulin dependent diabetes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1211794