Treatment for insect bites

Details Treatment for insect bites Treatment for insect bites

1995-03-01

1996-08-06

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Biocides; animal or insect repellents or attractants

424409, 514829, 514830, 514969, A61K 906

Patent

active

055431496

ABSTRACT:
A method and compositions for reducing the itch associated with the bite of a blood-feeding insect such as a mosquito or black fly are disclosed. The method entails applying a topical pharmaceutical formulation of papain, pancreatin or subtilisin, optionally including urea, to the skin proximate to the bite. Compositions are provided in the form of solutions, lotions, ointments and salves containing papain, pancreatin or subtilisin and, optionally, urea.

REFERENCES:
patent: 2917433 (1959-12-01), Goldman
patent: 3324002 (1967-06-01), Antonides
patent: 3409719 (1968-11-01), Noe et al.
patent: 3860702 (1975-01-01), Buell
patent: 4678668 (1987-07-01), Darras
patent: 5006562 (1991-04-01), Steltenkamp
Bilton, Chemical Abstracts, vol. 101, 1984, #157708p.
Hagermark "Influence of Antihistamines, Sedatives, and Aspirin on Experimental Itch" Acta Dermatovener 53, 363-368 (1973).
Agostinucci et al. "Effect of Papain on Bee Venom Toxicity" Toxicon 19, 851-855 (1981).
Rodeheaver et al. "Proteolytic Enzymes as Adjuncts to Antimicrobial Prophylaxis . . ." Amn. J. Surgery 129, 537-544 (1975).
Morgan "Topical Therapy of Pressure Ulcers" Surgery, Gynecology & Obstetrics 141, 945-947 (1975).

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