Treatment for inflammatory bowel disease with VLA-4 blockers

Details Treatment for inflammatory bowel disease with VLA-4 blockers Treatment for inflammatory bowel disease with VLA-4 blockers

1997-10-15

1999-08-03

Chan, Christina Y.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241301, 4241331, 4241341, 4241361, 4241411, 4241434, 4241531, 4241541, 514 2, 514 8, 514885, 530350, 5303871, 5303873, 5303881, 5303882, 53038822, 5303887, 53038873, 53038875, A61K 39395, A61K 3817

Patent

active

059322144

ABSTRACT:
A method for the treatment of inflammatory bowel disease (IBD) is disclosed. The method comprises administration of an antibody, polypeptide or other molecule recognizing VLA-4, a surface molecule expressed on most types of white blood cells and involved in leukocyte adhesion to endothelium and other tissus in the gut.

REFERENCES:
patent: 4816397 (1989-03-01), Boss et al.
patent: 4833092 (1989-05-01), Geysen
patent: 5116964 (1992-05-01), Capon et al.
patent: 5272263 (1993-12-01), Hession et al.
patent: 5730978 (1998-03-01), Wayner
Jakubowski, et al. "Vascular Cell Adhesion Molecule (VCAM)-Ig Fusion Protein Defines Distinct Affinity States of the Very Late Antigen-4 (VLA-4) Receptor" Cell Adhesion and Communication 3:131-142 (1995).
Brown, Jr., P. et al., "Anti-Tac-H, a Humanized Antibody to the Interleukin 2 Receptor, Prolongs Primate Cardiac Allograft Survival" Proc. Natl. Acad. Sci. USA 88:2663-2667 (1990).
Burkly, L. et al., "Signaling by Vascular Cell Adhesion Molecule-1 (VCAM-1) Through VLA-4 Promotes CD3-dependent T Cell Proliferation" Eur. J. Immunol. 21:2871-2875 (1991).
Clackson, T. et al., "Making Antibody Fragments Using Phage Display Libraries" Nature 352:624-628 (1991).
Co, M.S. et al., "Humanized Antibodies for Antiviral Therapy" Proc. Natl. Acad. Sci. USA 88:2869-2873 (1990).
Damle, N. et al., "Vascular Cell Adhesion Molecule 1 Induces T-cell Antigen Receptor-dependent Activation of CD4.sup.+ T Lymphocytes" Proc. Natl. Acad. Sci. USA 88:6403-6407 (1991).
Devlin, J. et al., "Random Peptide Libraries: A Source of Specific Protein Binding Molecules" Science 249:400-406 (1990).
Dobrina, A. et al., "Mechanisms of Eosinophil Adherence to Cultured Vascular Endothelial Cells" J. Clin. Invest. 88:20-26 (1991).
Elices, M.J. et al., "VCAM-1 on Activated Endothelium Interacts with the Leukocyte Integrin VLA-4 at a Site Distinct from the VLA-4/Fibronectin Binding Site" Cell 60:577-584 (1990).
Freedman, A. et al., "Adhesion of Human B Cells to Germinal Centers in Vitro Involves VLA-4 and INCAM-110" Science 249:1030-1033 (1990).
Harris, W.J. and S. Emery, "Therapeutic antibodies--the coming of age" TIBTECH 11: 42-44 (1993).
Hemler, M. E. et al., "Characterization of the Cell Surface Heterodimer VLA-4 and Related Peptides" J. Biol. Chem. 262(24):11478-11485 (1987).
Holzmann, B. and I.L. Weissman, "Integrin Molecules Involved in Lymphocyte Homing to Peyer's Patches" Immunolical Reviews 0(108):45-61 (1989).
Podolsky, D.K. et al., "Colonic Mucin Composition in Primates Selective Alterations Associated with Spontaneous Colitis in the Cotton-top Tamarin" Gastroent. 88:20-25 (1985).
Podolsky, D.K. et al., "Spontaneous Colitis In Cotton-Top Tamarins: Histologic, Clinical and Biochemical Features of an Animal Model of Chromic Colitis" Digestive Diseases and Sciences 30(4):396 (A-32) (1985).
Pulido, R. et al., "Functional Evidence for Three Distinct and Independently Inhibitable Adhesion Activities Mediated by the Human Integrin VLA-4" J. Biol. Chem. 266(16):10241-10245 (1991).
Rice, G.E. et al., "Vascular and Nonvascular Expression of INCAM-110", Am. J. Pathology 138(2):385-393 (1991).
Riechmann, L. et al., "Reshaping Human Antibodies for Therapy" Nature 332:323-327 (1988).
Salmi, M. and S. Jalkanen, "Regulation of Lymphocyte Traffic to Mucosa-Associated Lymphatic Tissues" Gastroent. Clin. N. Am. 20(3): 495-510(1991).
Sanchez-Madrid, F. et al., "VLA-3: A novel polypeptide association within the VLA molecular complex: cell distribution and biochemical characterization" Eur. J. Immunol. 16:1343-1349 (1986).
Scott, J.K. and G.P. Smith, "Searching for Peptide Ligands with an Epitope Library" Science 249:386-390 (1990).
Sherman-Gold, R., "Companies Pursue Therapies Based on Complex Cell Adhesion Molecules" Genetic Engineering News 13:6-7,14 (1993).
Springer, T.A., "Adhesion Receptors Of The Immune System" Nature 346:425-434 (1990).
Steiner, J. and J. Grindley, "Phase II Clinical Trial Results--Too Many Expectations?" Bio/Technology 11:644 (1993).
Stoolman, L.M., "Adhesion Molecules Controlling Lymphocyte Migration" Cell 56:907-910 (1989).
Taichman, D.B. et al., "Tumor Cell Surface .alpha..sup.4 .beta..sub.1 Integrin Mediates Adhesion to Vascular Endothelium: Demonstration of an Interaction with the N-Terminal Domains of INCAM-110/VCAM-1" Cell Regulation 2:347-355 (1991).
van Seventer, G.A. et al., "Analysis of T Cell Stimulation by Superantigen Plus Major Histocompatibility Complex Class II Molecules or by CD3 Monoclonal Antibody: Costimulation by Purified Adhesion Ligands VCAM-1, ICAM-1, but Not ELAM-1" J. Exp. Med. 174:901-913 (1991).
Waldmann, T.A., "Monoclonal Antibodies in Diagnosis and Therapy" Science 252:1657-1662 (1991).
Ward, E.S. et al., "Binding Activities of a Repertoire of Single Immunoglobulin Variable Domains Secreted From Escherichia coli" Nature 341:544-546 (1989).
Weller, P.F. et al., "Human Eosinophil Adherence to Vascular Endothelium Mediated by Binding to Vascular Cell Adhesion Molecule 1 and Endothelial Leukocyte Adhesion Molecule 1" Proc. Natl. Acad. Sci. USA 88:7430-7433 (1991).
Yuan, Q. et al., "Cloning and Sequence Analysis of a Novel .beta..sub.2 -Related Integrin Transcript from T Lymphocytes: Homology of Integrin Cysteine-Rich Repeats to Domain III of Laminin-B Chains" International Immunol. 2(11):1097-1108 (1990).
McNeil et al. JNCI 87: 1658-1660 (1995).
Mountain et al. Biotech Gen. Eng. Rev. 10: 1, 10-13 only (1993).
Edgington BioTechnology 20: 383-389 (1992).
Ward et al. Therapeutic Immunol. 1:165-171 (1994).
McCabe et al. Cell Immunol 150:364-375 (1993).
Paul Fundamental Immunol. p. 252 only Raven Press NY 1993.
Hemier Ann Rev Immunol 8:365-400 (1990).
Holzmann, B. et al., "Identification of a Murine Peyer's Patch-Specific Lymphocyte Homing Receptor as an Integrin Molecule with an .alpha. Chain Homologous to Human VLA-4.alpha." Cell 56:37-46 (1989).
Issekutz, T., "Inhibition of In Vivo Lymphocyte Migration to Inflammation and Homing to Lymphoid Tissues by the TA-2 Monoclonal Antibody" J. Immunol. 147:4178-4184 (1991).
Jones, P.T. et al., "Replacing the Complementarity-Determinig Regions in a Human Antibody with Those From a Mouse" Nature 321:522-525 (1986).
Jutila, M.A. et al., "Homing Receptors in Lymphocyte, Neutrophil, and Monocyte Interaction with Endothelial Cells" in Leukocyte Adhesion Molecules T.A. Springer et al. (eds.) (New York: Springer-Verlag New York Inc., 1990) Chp. 17, 227-235.
Kilshaw, P. and S.J. Murant, "Expression and Regulation of .beta..sub.7 (.beta.p) Integrins on Mouse Lymphocytes: Relevance to the mucosal Immune System" Eur. J. immunol. 21:2591-2597 (1991).
Kohler, G. and C. Milstein, "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity"Nature 265:495-497 (1975).
Koizumi, M. et al., "Expression of Vascular Adhesion Molecules in Inflammatory Bowel Disease" Gastroent. 103:840-847 (1992).
Lichtiger, S. and D.H. Present, "Preliminary Report: Cyclosporin in treatment of Severe Active Ulcerative Colitis" Lancet 336:16-19 (1990).
Lobb, R. et al., "Expression and Functional Characterization of a Soluble Form of Vascular Cell Adhesion Molecule 1" Biochem. Biophys. Res. Commun. 178(3):1498-1504 (1991).
Lobb, R. et al., "Expression and Functional Characterization of a Soluble Form of Endothelial-Leukocyte Adhesion Molecule" J. Immunol. 147(1):124-129 (1991).
Lobb, R. et al., "Vascular Cell Adhesion Molecule-1" in Cellular and Molecular Mechanisms of Inflammation: Vascular Adhesion Molecules vol. 2, C.G. Cochrane and M.A. Gimbrone, Jr. (eds.) (New York: Academic Press, Inc., 1991) Chp. 8, 151-169.
Madara, J. et al., "Characterization of Spontaneous Colitis in Cotton-Top Tamarin (Saguinus oedipus) and Its Response to Sulfasalazine", Gastroent. 88:13-19 (1985).
Malizia, G. et al., "Expression of Leukocyte Adhesion Molecules by Mucosal Mononuclear Phagocytes in Inflammatory Bowel Disease", Gastroent. 100:150-159 (1991).
Osband, M.E. and S. Ross, "Problems in the Investigational Study and Clinical Use of Cancer Immunotherapy" Immunol. Today 11:193-195 (1990).
Osborn, L., "Leukocyte Adhesion to Endothelium in Inflammati

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