Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1984-04-26
1986-07-22
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
A61K 31135
Patent
active
046020438
ABSTRACT:
This invention is for an improved method of treating the disease of hypoglycemia (low blood glucose), based on the discovery by the inventor of the etiology of the disease. The genesis of this invention is in the discovery that insulin alone does not control the uptake and regeneration of glucose by the liver. It has been discovered that hepatic storage of glucose following a meal requires the related function of insulin and serotonin. Hypoglycemia occurs during fasting and is due to an inappropriate release of serotonin to the liver. From this, the method of using a serotonin antagonist or an agent to block synthesis and/or storage of serotonin in timed relationship to ingested food to stop the action or the production of serotonin after glucose is no longer supplied to the portal vein is described. Then the liver can cease glucose uptake and begin production of glucose for the peripheral blood supply. The preferred antagonist is cyproheptadine.
REFERENCES:
Merck Index, 9th Ed. 362-363 (1976).
Friedman Stanley J.
Technology Unlimited Inc.
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