Treatment for hypertension or glaucoma in eyes

Details Treatment for hypertension or glaucoma in eyes Treatment for hypertension or glaucoma in eyes

1995-02-28

1997-02-04

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514573, 560121, 562503, C07C40500, A61K 31557

Patent

active

055998372

ABSTRACT:
The present invention relates to a 15-deoxyprostaglandin derivative of the formula (I): ##STR1## in which ##STR2## is a 5 membered ring which is selected from a group consisting of ##STR3## R.sup.1 is hydrogen or lower alkyl; R.sup.2 is C.sub.6 -C.sub.12 alkyl, C.sub.6 -C.sub.12 alkenyl or C.sub.6 -C.sub.12 alkadienyl;
provided that the compound of the following formula is excluded: ##STR4## wherein R' is hydrogen or methyl; or pharmaceutically acceptable salts thereof. The invention also relates to a pharmaceutical formulation comprising a 15-deoxyprostaglandin derivative as an active ingredient, which is useful as an intraocular pressure reducing agent.

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Goh et al., Japanese Journal of Ophthalmology, vol. 32, pp. 471-480, 1988, "Effects of Prostaglandin D.sub.2 and its Analogues on Intraocular Pressure in Rabbits".
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