Treatment for hypertension or glaucoma in eyes

Details Treatment for hypertension or glaucoma in eyes Treatment for hypertension or glaucoma in eyes

1992-09-21

1994-03-08

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514573, 514913, 206828, 560121, 562503, A61K 31557

Patent

active

052927547

ABSTRACT:
The present invention relates to a method for treating hypertension or glaucoma in the eye comprising contacting the surface of the eye with a therapeutic amount of a 15-deoxyprostaglandin derivative of the formula (I): ##STR1## in which ##STR2## is a 5 membered ring which is selected from a group consisting of ##STR3## R.sup.1 is hydrogen or lower alkyl; R.sup.2 is C.sub.6 -C.sub.12 alkyl, C.sub.6 -C.sub.12 alkenyl or C.sub.6 -C.sub.12 alkadienyl or a pharmaceutically acceptable salt thereof. The invention also relates to a kit for delivery of a topical solution for treatment of glaucoma which comprises (a) container having a solution including a compound of the formula (I), and (b) means for topical delivery of said solution to the eye in a controlled dosage.

REFERENCES:
patent: 4599353 (1986-07-01), Bito
Hamon et al., Tetrahedron Letters, No. 50, pp. 4481-4482 (1975).
Gorman et al., Chemical Abstracts 87(25): 194421c (1977).
Gorman et al., Proc. Natl. Acad. Sci., vol. 74, No. 9, pp. 4007-4011, Sep. 1977, "Inhibition of Human Platelet Thromboxane Synthetase by 9,11-azoprosta-5,13-dienoic Acid".
Greene et al., Protective Groups in Organic Synthesis, John Wiley & Sons, Inc., "Protection for the Hydroxyl Group, Including 1,2-and 1,3-diols" (1991).
Corey et al., Journal of the American Chemical Society, 93:6, Mar. 24, 1971, "Stereospecific Total Synthesis of Prostaglandins E.sub.3 and E.sub.3 .alpha.".
Goh et al., Japanese Journal of Ophthalmology, vol. 32, pp. 471-480, 1988, "Effects of Prostaglandin D.sub.2 and its Analogues on Intraocular Pressure in Rabbits".
Granstrom et al., Prostaglandins and Related Substances, pp. 7-13, IRL Press Limited, "Metabolism of Prostaglandins and Lipoxygenase Products: Relevance for Eicosanoid Assay" (1987).
Ohuchida et al., TET, vol. 39, No. 24-P, p. 4263, "Synthesis of Thromboxane A.sub.2 Analogs-2" (1982).
Prostaglandins: An Introduction to Their Biochemistry, Physiology and Pharmacology, pp. 23-27, 1976, Elsevier/North-Holland Biomedical Press, "Catabolism of Prostaglandins".
Ohuchida et al., J. Am. Chem. Soc., 1981, 103, pp. 4597-4599, "Synthesis of Trhomboxane A.sub.2 Analogues: DL-9,11:11,12-Dideoxa-9,11:11,12-diepithiothromboxane A.sub.2 ".
Collins, Journal of Medicinal Chemistry, vol. 29, No. 4, Apr. 1986, "Development and Therapeutic Role of Synthetic Prostaglandins in Peptic Ulcer Disease".

Affiliated with

Also associated with

Rating

Treatment for hypertension or glaucoma in eyes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Treatment for hypertension or glaucoma in eyes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment for hypertension or glaucoma in eyes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-153585