Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-07-21
1987-11-03
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514315, 514415, A61K 3144, A61K 31405, A61K 31445
Patent
active
047043946
ABSTRACT:
This invention is for an improved method of treating hyperkinetic behavior based on the discovery of the etiology of the disorder. The genesis of the invention is in the discovery that constant overactivity, distractibiity, impulsiveness, and aggressiveness, is frequently related to hypoglycemia. It has been discovered that hyperkinetic behavior due to moderate hypoglycemia will respond favorably, to the treatment of hypoglycemia. Hypoglycemia occurs during fasting and is due to an inappropriate presence of serotonin at the liver. Serotonin is a key hormone in conjunction with insulin to program liver glucose control. From this, the method is described of using a serotonin antagonist or an agent to block synthesis and/or storage of serotonin after glucose is no longer supplied to the portal vein. Then the liver can cease glucose uptake and begin production of glucose for the peripheral blood supply. The preferred serotonin antagonist is cyproheptadine.
Increased blood serotonin levels, in a fasting state, causes hepatic retention of glucose and a degree of hypoglycemia. The body corrects the hypoglycemia by activating the adrenergic nervous system. Adrenergic correction of hypoglycemia is followed by regression, then adrenergic correction again on and on in prolonged cycle. The adrenergic correction is associated with overactivity and behavioral (characteristics associated with the well known "fight and flight" response). Although the activity lessens as a child grows older, and often disappears by adolescence, some mental disorders are probably the result of prolonged mild hypoglycemia.
Friedman Stanley J.
Technology Unlimited Inc.
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