Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1991-07-01
1992-04-07
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514812, A61K 3119
Patent
active
051029138
ABSTRACT:
The craving for cocaine and use of cocaine among users may be reduced by administration of valproic acid. Cocaine-usage is effectively treated with valproic acid administration.
REFERENCES:
patent: 4942182 (1990-07-01), Weiss et al.
patent: 5028611 (1991-07-01), Halikas
Halikas et al., "Carbamazepine for Cocaine Addiction?", The Lancet, Mar. 18, 1989, pp. 623-624.
Dackis et al., Arch. Gen. Psychiatry, 44:298-299, 1987.
Dackis and Gold, "Pharmacological Approaches to Cocaine", J. Subst. Abuse Treat., 2:139-145 (1985).
Post et al., "The Role of Context and Conditioning in Behavioral Sensitization to Cocaine", Pharm. Bulletin, vol. 23, No. 3, pp. 425-429 (1987).
Post et al., "Kindling and Drug Sensitization: implications for the progressive development of psychopathology and treatment with carbamazepine", The Psychopharmacology of Anticonvulsants, pp. 27-53 (1981).
Post, "Time Course of Clinical Effects of Carbamazepine: Implications for Mechanisms of Action", J. Clin. Psychiatry, 49:4(Suppl), Apr. 1988, pp. 35-46.
Post et al. in "Differential Effects of Carbamazepine and Lithium on Sensitization and Kindling", Prog. Neuro-Psychopharmacol & Biol Psychiat., 1984, vol. 8, pp. 425-434.
Ballenger et al., "Kindling as a Model for Alcohol Withdrawal Syndromes", Brit. J. Psychiat., (1978), 133, 1-14.
Post et al., "Conditioning, Sensitization, and Kindling: Implications for the Course of Affective Illness," Chapter 28, pp. 432-466 of Neuro. Bio. of Mood Disorders, (1984).
"Tegretol Said to Be Valuable Drug in Treatment of Benzodiazepine Withdrawal", Psychiatric News, May 5, 1989.
Article from Minneapolis Star/Tribune, Sep. 12, 1989 entitled, "Cure for Craving? Psychiatrist thinks he has found pill to battle cocaine".
Ballenger et al., "Neurobiological Correlates of Depression and Anxiety in Normal Individuals", Date and Publication not available, chapter 30, pp. 481-501.
"Winning the Drug War One Battle at a Time", University of Minnesota Medical Bulletin, Summer 1990 p. 6.
"Dr. James Halikas Finds That A Pill Made for Seizures May Help Cocaine Addicts To Just Say No", People Weekly, 33:3 p. 81 (1990).
Gawin and Ellinwood, "Cocaine and Other Stimulants: Actions, Abuse and Treatment", New England Journal of Medicine, 318:18 p. 1173 (1988).
Giannini and Billett, "Bromocriptine-Desipramine Protocol in Treatment of Cocaine Addiction", J. Clin. Pharmacol 1987; 27:549-554.
Post and Weiss, "Sensitization, Kindling, and Anticonvulsants in Mania", J. Clin. Psychiatry 50:12 (Suppl.) Dec. 1989.
Perez-Reyes et al, "Free-base Cocaine Smoking", Clin. Pharmacol. Ther., Oct. 1982, p. 459.
Tennant et al, "Double-Blind Comparison of Desipramine and Placebo for Treatment of Phencyclidine or Amphetamine Dependence".
Kleber and Gawin, "Psychopharmacological Trials in Cocaine Abuse Treatment", Am. J. Drug Alcohol Abuse 12(3) pp. 235-246 (1986).
Cocores et al, "Cocaine Abuse and Adult Attention Deficit Disorder", J. Clin. Psychiatry 48:9, p. 376, Sep. 1987.
Resnick and Resnick, "Cocaine Abuse and its Treatment", Psychiatric Clinics of North America, 7:4, p. 713, Dec. 1984.
Kleber, "Introduction: Cocaine Abuse: Historical, Epidemiological, and Psychological Perspectives", J. Clin. Psychiatry 49:2, p. 3 (Suppl) Feb. 1988.
Fischman, "Behavioral Pharmacology of Cocaine", J. Clin. Psychiatry 49:2, p. 7 (Suppl) Feb. 1988.
Gawin, "Chronic Neuropharmacology of Cocaine: Progress in Pharmacotherapy", J. Clin. Psychiatry 49:2 p. 11 (Suppl) Feb. 1988.
O'Brien et al., "Pharmacological and Behavioral Treatments of Cocaine Dependence: Controlled Studies", J. Clin. Psychiatry 49:2, 17 (Suppl) Feb. 1988.
Baxter, Jr. et al, "Localization of Neurochemical Effects of Cocaine and Other Stimulants in the Human Brain", J. Clin. Psychiatry 49:2 p. 23 (Suppl) Feb. 1988.
Millman, "Evaluation and Clinical Management of Cocaine Abusers", J. Clin. Psychiatry 49:2 p. 27 (Suppl) Feb. 1988.
Blumer et al., "Indications for Carbamazepine in Mental Illness: Atypical Psychiatric Disorder or Temporal Lobe Syndrome?", Comprehensive Psychiatry, 29:2, pp. 108-122 (1988).
Price et al., "Management of Acute PCP Intoxication with Verapamil", Clinical Toxicology, 24(1), 85-87 (1986).
Karler et al., "Blockade of `Reverse Tolerance` to Cocaine and Amphetamine by MK-801", Life Sciences, 45:599-606 (1989).
Scher and Neppe, "Carbamazepine Adjunct for Nonresponsive Psychosis with Prior Hallucinogenic Abuse", Journal of Nervous and Mental Disease, 177:12, p. 755 (1989).
Brown et al., "Alcohol Detoxification and Withdrawal Seizures: Clinical Support for a Kindling Hypothesis", Biol Psychiatry 23:507-514 (1988).
Smith, David E., "Diagnostic, Treatment and Aftercare Approaches to Cocaine Abuse", from Journal of Substance Abuse Treatment, vol. 1 pp. 5-9, 1984.
Nursing 89 Drug Handbook, Springhouse Corp., Springhouse, PA (1989) pp. 264, 280.
Nahas, G. et al., Bull Acad Natl Med 173(9):1199-1206, 12/89 (Abstract).
Gale, K., NIDA Res Monogr Ser 54:323-332, 1984 (Abstract).
Post, R. M. et al., Neuro-Psychopharmacol Biol Psychiatr 7(2-3);263-271, 1983.
Gardner Diane
Waddell Frederick E.
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