Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-07
1998-07-21
O'Sullivan, Peter
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
424 91, 424 92, 436 71, 436 86, 436129, 514 18, 5142262, 514477, 514478, 514479, 514484, 514485, 514487, 514488, 514489, 514506, 514513, 514517, 514518, 514553, 514561, 514824, 514825, 514826, 514861, 514863, 530331, 548431, 548531, 549 10, 558230, 558234, 558235, 558250, 562 26, 562 27, 564 76, 568 21, 568 25, A61K 3140, A61K 3154, A61K 31265, A61K 31185
Patent
active
057835969
ABSTRACT:
Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.
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Alexander R. Wayne
Medford Russell M.
Offermann Margaret K.
Parthasarathy Sampath
Emory University
Haley Jacqueline
Knowles Sherry M.
O'Sullivan Peter
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