Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-06-07
1998-06-30
O'Sullivan, Peter
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
424 91, 424 92, 435 6, 435 72, 435 721, 435 794, 435 795, 436 71, 436 86, 436129, 436172, 436503, 436504, 436548, 514 18, 514423, 514478, 514479, 514484, 514485, 514487, 514488, 514489, 514506, 514513, 514824, 514825, 514826, 514861, 514863, 530331, 548431, 558230, 558235, 564 76, 568 21, 568 25, G01N 3353
Patent
active
057732310
ABSTRACT:
A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.
REFERENCES:
patent: 3875170 (1975-04-01), Montsumoto et al.
patent: 4056621 (1977-11-01), Brown et al.
patent: 4112104 (1978-09-01), Durant et al.
patent: 4522811 (1985-06-01), Eppstein et al.
patent: 4670471 (1987-06-01), Clark
patent: 4868116 (1989-09-01), Morgan et al.
patent: 4870101 (1989-09-01), Ku et al.
patent: 4900750 (1990-02-01), Archibold et al.
patent: 4980286 (1990-12-01), Morgan et al.
patent: 5035878 (1991-07-01), Borch et al.
patent: 5166133 (1992-11-01), Houston et al.
patent: 5206264 (1993-04-01), Marangus
patent: 5306724 (1994-04-01), Goldberg
Agrawal, et al., "Oligodeoxynucleoside phosphoramidates and phosphorothioates as inhibitors of human immuodeficiency virus," Proc. Natl. Acad. Sci. USA, 85:7079-7083 (1988).
Alvarez, D.E.M.J., R. Montoro, et al. (1986), "Determination of cadmium, copper, and lead in sodium chloride food salts by flame atomic absorption spectroscopy," J. Assoc. Off. Anal. Chem. 68(5): 871-3.
Baselt, R.C., F.W.J. Sunderman, et al. (1977), "Comparisons of antidotal efficacy of sodium diethyldithiocarbamate. D-penicillamine an triethylenetramine upon acute toxicity of nicekl carbonyl in rats," Res. Commun. Chem. Pathol. Pharmacol. 18(4):677-88.
Biorkhem, I.F.,A. Henriksson, et al. (1991), "The antioxidant butylated hydroxytoluene protects against atherosclerosis," Arterioscler. Thromb. 11(1):15-22.
Blume, et al., "Triple helix formation by purine-rich oligonucleotides targeted to the human dihydrofolate reductase promoter," Nucl. Acids. Res., 20:1777-1784 (1992).
Brown and Langer, "Transdermal Delivery of Drugs," Annual Review of Medicine, 39:221-229 (1988).
Carew, T.E., D.C. Schwenke, et al., (1987), "Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Wantanabe heritable hyperlipidemic rabbit," Proc. Natl. Acad. Sci. U.S.A. 84(21):7725-9.
Cooney, et al., "Site-Specific Oligonucleotide Binding Represses Transcription of the Human c-myc Gene in Vitro," Science, 241:456-459 (1988).
Corke C.F., (1984) "The influence of diethyl-dithiocarbamate (`Imuthiol`) on mononuclear cells in vitro." Int. J. Immunoparamacol. 6(3):245-7.
Crooks, "Progress toward oligonucleotide therapeutics: pharmacodynamic properties," FASEB J. 7:533-539 (1993).
Cybulsky, et al., "Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis," Science, 251:788-791 (1991).
Donner, M., P.K. Husgafvel, et al. (1983), "Mutagenicity of rubber additives and curing fumes. Results from five short-term bioassays," Scand J. Work Environ. Health 9(2):27-37.
Duval-Valentin, et al., "Specific inhibition of transcription by triple helix-forming oligonucleotides," Proc. Natl. Acad. Sci. USA, 89:504-508 (1992).
Eltaveb, M.A. and G.R.E. Van (1990), "Iron, copper, zinc and lead in hair from Sudanese populations of different age groups," Sci. Total Environ. 95:157-65.
Evans, R.G., J. Nielsen, et al. (1983), "Enhancement of heat sensitivity and modification of repair of potentially lethal heat damage in plateau-phase cultures of mammalian cells by diethyldithiocarbamate," Radiat. Res. 93(2):319-25.
Fishbein, L. (1976), "Environmental health aspects of fungicides, I, Dithiocarbamates," J. Toxicol. Environ. Health 1(5):713-35.
Fishbein, L. (1978), "Overview of potential mutagenic problems posed by some pesticides and their trace impurities," Environ. Health Perspect. 27:125-31.
Fruebis, et al., "Evidence for a concerted reaction between lipid hydroperoxides and polypeptides," Proc. Natl. Acad. Sci. USA, 89:10588-10592 (1992).
Gale, G.R., A.B. Smith, et al., "Diethyldithiocarbamate in treatment of acute cadmium poisoning," Ann. Clin. Lab. Sci. 11(6):476-83 (1981).
Grigoriev, et al., "A Triple Helix-forming Oligonucleotide-Intercalator Conjugate Acts as a Transcriptional Repressor via Inhibition of NF kB Binding to Interleukin-2 Receptor Alpha-Regulatory Sequence," J. Biol. Chem., 267:3389-3395 (1992).
Hacker, M.P., W.B. Ershler, et al., "Effect of disulfiram (tetraethylthiuram disulfide) and diethyldithiocarbamate on the bladder toxicity and antitumor activity of cyclophosphamide in mice," Cancer Res. 42(11):4490-4 (1982).
Hemavathy, K.C. and N. B. Krishnamurthy, "Cytogentic effects of Cuman L, a dithiocarbamate fungicide," Mutat. Res. 208(1):57-60 (1988).
Holt, et al., "An Oligomer Complementary to c-myc mRNA Inhibits Proliferation of HL-60 Promyelocytic Cells and Induces Differentiation," Mol. Cell. Biol., 8:963-973 (1988).
Hording, Merete, P.C. Gotzsche, et al., "Lack of immunomodulating effect of disulfiram on HIV positive patients," J. Immunopharmac. 12(2):145-147 (1990).
Iademarco, et al., "Characterization of the Promoter for Vasculr Cell Adhesion Molecule-1 (VCAM-1)," J. of Biol. Chem., 267(23):16323-16329 (1992).
Itakura, et al., "Synthesis and Use of Synthetic Oligonucleotides," Ann. Rev. Biochem., 53:323-356 (1984).
Inoue, K., M., Fukunaga, et al., "Effect of dislfiram and its reduced metabolite, diethyldithiocarbamate on-aldehyde dehydrogenase of human erythrocytes," Life Sci. 30(5):419-24 (1982).
Jones, M.M. and M.G. Cherian, "The search for chelate antagonists for chronic cadmium intoxication," Toxicology 62(1):1-25 (1990).
Jones, S.G., M.A. Basinger, et al., "A comparison of diethyldithiocarbamate and EDTA as antidotes for acute cadmium intoxication," Res. Commun. Chem. Pathol. Pharmacol. 38(2):271-8 (1982).
Ku, G., N.S. Doherty, et al., "Ex vivo lipopolysaccharide-induced interleukin-1 secretion from murine peritoneal macrophages inhibited by probucol, a hypocholesterolemic agent with *antioxidant* proprieties," Faseb J. 4(6):1645-53 (1990).
Lang, J.M., C. Trepo, et al., "Randomised, double-blind, placebo-controlled trial of ditocarb sodium (`Imuthiol`) in human immunodeficiency virus infection," The Lancet Sep. 24, 1988:702-706 (1988).
Lemarie, E., M. Musset, et al., "Clinical characterization of imuthiol," Methods Find Exp. Clin. Pharmacol. 8(1):51-4 (1986).
Lin, P.S., L. Kwock, et al., "Copper chelator enhancement of bleomycin cytotoxicity," Cancer 46(11):2360-4 (1980).
Maher, et al., "Inhibition of DNA Binding Proteins by Oligonucleotide-Directed Triple Helix Formation," Science, 245:725-730 (1989).
Marui, et al., "Vascular Cell Adhesion Molecule-1 (VCAM-1) Gene Transcription and Expression are Regulated Through an Antioxidant-Sensitive Mechanism in Human Vascular Endothelial Cells," J. of Clin. Invest., 92(4):1866-1874 (1993).
Menne, T. and K. Kaaber, "Treatment of pompholyx due to nickel allergy with chelating agents," Contact Dermatitis 4:(5):289-90 (1978).
Miller, D.B., "Neurotoxicity of the pesticidal carbamates," Neurobehav, Toxicol. Teratol. 4(6):779-87 (1982).
Moerlein, S.M., A. Daugherty, et al., "Utility of Tc-99m-and in -111-labelled low-density lipoprotein as radiopharmaceuticals for metabolic imaging," J. Nuclear Medicine 32:(1) 925-926 (1991).
Mulligan, "The Basic Science of Gene Therapy," Science, 260:926-932 (1993).
Narang, et al., "Chemical Synthesis of Deoxyoligonucleotides by the Modified Triester Method," Methods Enzym
Alexander R. Wayne
Khan Bobby V.
Medford Russell M.
Parthasarathy Sampath
Emory University
Knowles Sherry M.
O'Sullivan Peter
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