Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ortho-hydroxybenzoic acid or derivative doai
Patent
1995-06-06
1998-12-08
O'Sullivan, Peter
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ortho-hydroxybenzoic acid or derivative doai
424 91, 424 92, 424 6, 424 72, 424 721, 424 724, 424 794, 424 795, 436 71, 436 86, 436129, 436172, 436503, 436504, 436548, 514 18, 514165, 514171, 514211, 514423, 514457, 514478, 514479, A61K 3160, A61K 3156, A61K 3140, A61K 3137
Patent
active
058469591
ABSTRACT:
A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.
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Alexander R. Wayne
Khan Bobby V.
Medford Russell M.
Parthasarathy Sampath
Emory University
Haley Jacqueline
Knowles Sherry M.
O'Sullivan Peter
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