Treatment and prevention of mucositis in cancer patients

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S724000

Reexamination Certificate

active

06841578

ABSTRACT:
The invention features a method for the treatment or prevention of mucositis in an individual undergoing or preparing to undergo cancer treatment. The method includes administering a therapeutically effective amount of an inhibitor of NF-κB to an individual undergoing or preparing to undergo a treatment for cancer. In certain embodiments, the inhibitor is a compound having the formula:where R1and R4are OH, and R2and R3are independently OH or H, provided that when R1and R2are both OH, R1and R2cannot be disposed ortho to one another, and when R3and R4are both OH, R3and R4cannot be disposed ortho to one another. The compounds of formula I may be cis or trans.

REFERENCES:
patent: 5496828 (1996-03-01), Cullinan
patent: 5891924 (1999-04-01), Aggarwal
patent: 5916910 (1999-06-01), Lai
patent: 6274601 (2001-08-01), Cullinan
patent: 20010011097 (2001-08-01), Sonis et al.
Moghadam B. K, et al., “Autoimmune progesterone dermatitis and stomatitis.”, Abstract from Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, 85(5), pp. 537-541, May 1998.*
Goldberg, et al., “Direct Injection Gas Chromatographic Mass Spectrometric Assay fortrans-Resveratrol”, Anal. Chem. 66 (1994) p. 3959-3963.
Jeandet et al., “The Production of Resveratrol (3,5,4′-trihydroxystilbene) by Grape Berries in Different Developmental Stages”, Am. J. Enol. Vitic. 42 (1991) p. 41-46.
Manna, et al., “Resveratrol Suppresses TNF-Induced Activation of Nuclear Transcription Factors NF-κB, Activator Protein-1, and Apoptosis: Potential Role of Reactive Oxygen Intermediates and Lipid Peroxidation”, J. Immunol. 164 (2000) p. 6509-6519.
Mohan, et al., “The Neurohormone Melatonin Inhibits Cytokine, Mitogen and Ionizing Radiation Induced NF-κB”, Biochem. Mol. Biol. Int. 37 (1995) p. 1063-70.
Stojanovic; et al., “Efficiency and Mechanism of the Antioxidant Action oftrans-Resveratrol and its Analogues in the Radical Liposome Oxidation”, Arch. Biochem. Biophy. 391 (201) p. 79-89.
Database HCAPLUS on STN, No. 2002:598692, Takeuchi et al. Nuclear Factor-kappa B and TNF.-alpha. Mediate Gastric Ulceration Induced by Pharbol Myristate Acetate, abstract, Digestive Diseases and Sciences, Apr. 2002, 47(9), 2070-2078.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Treatment and prevention of mucositis in cancer patients does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Treatment and prevention of mucositis in cancer patients, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment and prevention of mucositis in cancer patients will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3399074

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.