Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-04-14
2009-11-03
Landau, Sharmila Gollamudi (Department: 1611)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S311000, C514S430000, C514S443000, C514S456000
Reexamination Certificate
active
07612107
ABSTRACT:
The present invention contemplates methods of treating, reducing, inhibiting or preventing several diseases by the administration of flexible heteroarotinoids. Among the diseases or conditions which can benefit from treatment with flexible heteroarotinoids as described herein are, (1) cancers and other diseases that involve abnormal differentiation, (2) diabetes, (3) hemophilia, (4) liver disease, (5) diseases involving human aldehyde dehydrogenase 2, (6) polycystic kidney disease, (7) lysosomal storage diseases, (8) high cholesterol, (9) obesity, (10) high triglycerides, (11) glycoprotein metabolism diseases, and (12) diseases involving abnormal angiogenesis.
REFERENCES:
patent: 6586460 (2003-07-01), Berlin et al.
Mangoo-Karim et al, 1989, Physiology Sciences, PNAS, vol. 86, pp. 6007-6011).
Guay-Woodford, 2003, Am J Physiol Renal Physiol, vol. 285, pp. F1034-F1049.
Nelson et al., 2006, Nephron Exp Nephrol, vol. 103, Issue 1, pp. e6-15.
Abstract: Document No. 140:199479 (Lui, et al., “Synthesis of Flexible Sulfur-Containing Heteroarotinoids that Induce Apoptosis and Reactive Oxygen Species with Discrimination between Malignant and Benign Cells”, Journal of Medicinal Chemistry, 2004, vol. 47, No. 4, pp. 999-1007).
Benbrook Doris M.
Guruswamy Suresh
Turman Martin
Dunlap Codding P.C.
Frazier Barbara
Landau Sharmila Gollamudi
The Board of Regents of the University of Oklahoma
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