Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1997-07-17
2000-10-24
Eyler, Yvonne
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241381, 4241391, 5303877, 5303888, 5303879, A61K 39395, C07K 1600, C12P 2108
Patent
active
061363111
ABSTRACT:
The present invention is directed to the use of antibodies or binding portions thereof, probes, ligands, or other biological agents which either recognize an extracellular domain of prostate specific membrane antigen or bind to and are internalized with prostate specific membrane antigen. These biological agents can be labeled and used for detection of cancerous tissues, particularly cancerous tissues proximate to or containing vascular endothelial cells, which express an extracellular domain of prostate specific membrane antigen. The labeled biological agents can also be used to detect normal, benign hyperplastic, and cancerous prostate epithelial cells or portions thereof. They also can be used alone or bound to a substance effective to ablate or kill such cells as a therapy for prostate or other cancers. Also disclosed are four hybridoma cell lines, each of which produces a monoclonal antibody recognizing extracellular domains of prostate specific membrane antigens of normal, benign hyperplastic, and cancerous prostate epithelial cells or portions thereof.
REFERENCES:
patent: 4814275 (1989-03-01), Durda et al.
patent: 4863851 (1989-09-01), McEwan et al.
patent: 4863854 (1989-09-01), Mattes et al.
patent: 5013645 (1991-05-01), Kim
patent: 5118611 (1992-06-01), Smith et al.
patent: 5162504 (1992-11-01), Horoszewicz
patent: 5227471 (1993-07-01), Wright, Jr.
patent: 5229289 (1993-07-01), Kjeldsen et al.
patent: 5314996 (1994-05-01), Wright, Jr.
patent: 5342924 (1994-08-01), Chang
patent: 5489525 (1996-02-01), Pastan
patent: 5538866 (1996-07-01), Israeli et al.
patent: 5599677 (1997-02-01), Dowell et al.
patent: 5855866 (1999-01-01), Thorpe et al.
patent: 5877289 (1999-03-01), Thorpe et al.
Jain, R.K. "Vacular and interstitial barriers to delivery of therapeutic agents in tumors" Cancer and Metastasis Reviews. vol. 9, p. 253-266, 1990.
Troyer et al., "Location of prostate-specific membrane antigen in the LNCaP prostate carcinoma cell line," Prostate, 30:232-242. (1997).
Liu, et al., "Monoclonal Antibodies to the Extracellular Domain of Prostate-specific Membrane Antigen also React with Tumor Vascular Endothelium," Cancer Res. 57:3629-34 (1997).
Chang et al., "Five Different Anti-Prostate-specific Membrane Antigen (PSMA) Antibodies Confirm PSMA Expression in Tumor-associated Neovasculature," Cancer Res., 59:3192-3198 (1999).
Liu, et. al., "Constitutive and Antibody-Induced Internalization of Prostate-Specific Membrane Antigen," Cancer Res. 58:4055-60 (1998).
Silver et al., "Prostate-specific Membrane Antigen Expression in Normal and Malignant Human Tissues," Clin. Cancer Res., 3:81-85 (1997).
Yang et al., AACR Abstract #2996 (1998); "Alpha particle emitter therapy of micrometastases: .sup.213 Bi-J5 . . . (anti-PSMA) treatment of LNCaP spheroids," Proceedings of the American Association for Cancer Research, 39:440 (1998).
Horoszewicz et al., "Monoclonal Antibodies to a New Antigenic Marker in Epithelial Prostatic Cells and Serum of Prostatic Cancer Patients," Anticancer Research, 7:927-936 (1987).
Israeli et al., "Molecular Cloning of a Complementary DNA Encoding a Prostate-Specific Membrane Antigen," Cancer Research, 53:227-230 (1993).
Israeli et al., "Expression of the Prostate-Specific Membrane Antigen," Cancer Research, 54:1807-1811 (1994).
Rochon et al., "Western Blot Assay for Prostate-Specific Membrane Antigen in Serum of Prostate Cancer Patients," The Prostate, 25:219-223 (1994).
Troyer et al., "Biochemical Characterization and Mapping of the 7EII-C5.3 Epitope of the Prostate-Specific Membrane Antigen," Urol Oncol, 1:29-37 (1995).
Troyer et al., "Detection and Characterization of the Prostate-Specific Membrane Antigen (PSMA) in Tissue Extracts and Body Fluids," Int. J. Cancer, 62:552-558 (1995).
Wright et al., "Expression of Prostate-Specific Membrane Antigen in Normal, Benign, and Malignant Prostate Tissues," Urol Oncol, 1:18-28 (1995).
Murphy et al., "Measurement of Prostate-Specific Membrane Antigen in the Serum With a New Antibody," The Prostate, 28:266-271 (1996).
Cornell Research Foundation Inc.
Eyler Yvonne
Nickol Gary B.
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