Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2007-03-13
2007-03-13
Peselev, Elli (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S152000, C514S179000
Reexamination Certificate
active
09227749
ABSTRACT:
The invention relates to a method of treating Alzheimer's disease in a mammal comprising administering to the mammal an anti-microbial agent having anti-Chlamydia pneumoniaeactivity. The invention also relates to a method of diagnosing Alzheimer's disease in a mammal comprising measuring the serum anti-Chlamydia pneumoniaeantibody titer in a patient suspected of having Alzheimer's disease.
REFERENCES:
patent: 4419365 (1983-12-01), McLachlan
patent: 5034506 (1991-07-01), Summerton et al.
patent: 5424187 (1995-06-01), Shor et al.
patent: 5700816 (1997-12-01), Isakson et al.
patent: 5789395 (1998-08-01), Amin et al.
patent: 5846220 (1998-12-01), Elsberry
patent: 5880101 (1999-03-01), Stankov
patent: 5919775 (1999-07-01), Amin et al.
patent: 6255347 (2001-07-01), Xiaotao et al.
patent: 6579854 (2003-06-01), Mitchell et al.
patent: 6664239 (2003-12-01), Mitchell et al.
patent: WO 96/00576 (1996-01-01), None
Abrams et al. ,1991, J. Immunol. 146:1455-1462.
Abrams et al., 1993, Cancer Res. 53:5501-5506.
Abrams et al. ,1991, J. Invest. Dermatol. 96:31-37.
Alonso et al., 1996, Nature Med. 2:783-787.
Andersen et al., 1995, Neurology 45:1441-1445.
Appelt et al., 1996, J. Histochem. Cytochem. 44:1421-1427.
Barbas, 1995, Nature Medicine 1:837-839.
Bird et al., 1988, Science 242:423-426.
Blacker et al., 1997, Neurol. 48:139-147.
Bolton et al., 1993, Ann. Neurol. 33:94-100.
Branigan et al., 1996, Arthritis Rheumat. 39:1740-1746.
Breitner et al., 1994, Neurology 44:227-232.
Breteler et al., 1992, Epidemiol. Rev. 14:59-82.
Bretschneider et al., 1981, Am. J. Clin Path. 76:450-453.
Burton and Barbas, 1994, Adv. Immunol. 57:191-280.
Campbell et al., 1995, J. Infect. Dis. 172:585-588.
Capron, 1996, Nature Med. 2:856-857.
Chakravarthy et al., 1995, Curr. Eye Res. 14:285-294.
Clark et al., 1993, Arch. Neurol. 50:1164-1172.
Connors et al., 1995, Stem Cells, 13:501-511.
Cook et al., 1996, Proc. Natl. Acad. Sci. USA 93:9223-9228.
Corder et al., 1993, Science 261-921-923.
de Kruif et al., 1995, J. Mol. Biol.248:97-105.
Evans et al., 1989, J. Amer. Med. Assn. 262:2551-2556.
Friedland et al., Arch. Neurol. 47:177-178.
Gautrin et al., 1989, Can. J. Neurol. Sci. 16:375-387.
Gaydos et al., 1992, J. Clin. Microbiol. 30:796-800.
Gran et al., 1993, Scand. J. Rheumatol. 22:43-44.
Grayston et al., 1993, J. Infec. Dis. 168:1231-1235.
Grayston, 1992, Ann.. Rev. Med. 43:317-323.
Grayston et al., 1990, J. Infect. Dis. 161:618-625.
Greenberg, 1990, Proc. Natl. Acad. Sci. USA 87:5827-5831.
Gu et al., 1997, Thrombosis and Hematocyst 77(4):755-759.
Hahn et al., 1991, J. Amer. Med. Assn. 266:225-230.
Hatch, 1998, Science 282:754-759.
Hixson et al., 1990, J. Lipid Res. 31:545-548.
Hofman et al., 1997, Lancet 349:151-153.
Huston et al., 1988, Proc. Natl. Acad. Sci. USA 85:5879-5883.
Itzhaki et al., 1997, Lancet 349:241-244.
Johnson, 1994, J. Neurol. Sci. 124:3-14.
Keefover, 1996, Neurol. Clin. 14:337-351.
Kingsbury et al., 1995, Mol. Brain Res. 28:311-318.
Koskiniemi et al., 1996, Eur. Neurol. 36:160-163.
Kurosaka et al., 1998, J. Immunol. 161:6245-6249.
Lee et al., 1991, Science 251:675-679.
Lee et al., 1996, J. Neurosci. 16:7513-7525.
Leinonen, 1993, Eur. Heart J. 14:57-61.
Lemere et al., 1996, Nature Med. 2:1146-1150.
Li et al., 1998, Cell Biol. Int. 22:13-20.
Li et al., 1996, Arthritis Rheumat. 39:950-958.
Lippa et al., 1996, Neurol. 46:406-412.
Löbau et al., 1995, Mol. Microbiol. 18:391-399.
Lomax et al., 1990, Gene 86:209-216.
Malinverni, 1996, Curr. Opin. Infect. Dis. 9:150-156.
Mann et al., 1983, Acta Neurol. 60:24-28.
Marks et al., 1991, J. Mol. Biol. 222:581-597.
McKee et al., 1991, Ann. Neurol. 30:156-165.
McKhann et al., 1984, Neurology 34:939-994.
Mehta et al., 1998, J. Infect. Dis. 177:1326-1331.
Melgosa et al., 1991, Infect. Immunol. 59:2195-2199.
Melgosa et al., 1994, Infect Immun. 62:880-886.
Merrill et al., 1993, J. Immunol. 151:2132-2141.
Mirra et al., 1991, Neurology 41:479-486.
Miyashita et al., 1993, J. Med Microbiol. 38:418-425.
Montarras et al., 1994, In: The Polymerase Chain Reaction, Mullis et al., eds., Birkhäuser, Press, Boston, MA, pp. 277-294.
Muhlestein et al., 1996, J. Amer. Coll. Cardiol. 27:1555-1561.
Nielsen et al., 1991, Science 254:1497-1500.
Numazaki et al., 1995, J. Med. Microbiol. 42:191-195.
Peterson et al., 1998, Infect. Immun. 66:3848-3855.
Peterson et al., 1996, Infect. Immun. 64:3354-3359.
Pogo et al., 1987, Brain 110:907-915.
Poulakkainen et al., 1995, Microbiol. Immunol. 39:551-554.
Renvoize et al., 1987, Age and Ageing 16:311-314.
Rogers et al., 1993, Neurology 43:1609-1611.
Roses, 1996, Ann. Rev. Med. 47:387-400.
Schellenberg, 1995, Proc. Natl. Acad. Sci. USA 92:8552-8559.
Sriram et al., 1998, Neurol. 50:571-572.
Stagg, 1998, Mol. Med. Today 4:166-173.
Strugnell et al., 1997, Immunol. Cell Biol. 75:364-369.
Tuszynski et al., 1988, Blood, 72:109-115.
Waldman, 1991, Science 252:1657-1662.
Wang et al., 1996, Nature Med. 2:871-875.
Whittum-Hudson et al., 1996, Nat. Med. 2:1116-1121.
Wimmer et al., 1996, Stroke 27:2207-2210.
Wisniewski et al., 1988, Ciba Fdn. Sympos. 135:224-238.
Wong et al., 1992, J. Clinical Microbiol. 30:1625-1630.
Wright et al., 1992, Critical Rev. in Immunol. 12(3,4):125-168.
Yankner, 1996, Nature Med. 2:850-852.
Zhang et al., 1997, J. Infect. Dis. 176:1035-1040.
Jaruratanasirikul et al., Mar. 1996, “Distribution of Azithromycin Into Brain Tissue, Cerebrospinal Fluid, and Aqueous Humor of the Eye”,Antimicrobial Agents and Chemotherapy,vol. 40, No. 3, p. 825-826.
Matthews, 1986, Neuropathology and Applie Neurobiology 12:111-116.
Morbidity and Mortality Weekly Report, CDC, 1993 Sexually Transmitted Diseases Treatment Guidelines, 42:No. RR-14.
Balin, Brian J. et al. “Identification and Localization of Chlamydia Pneumoniae in the Alzheimer's Brain,” Med Microbiol Immunol, 187:23-42, 1998.
Mahony, James B. et al. “Identification of Chlamydia Pneumoniae in the Alzheimer's Brain,” World Alzheimer Congress 2000, Pivotal Research, Washington, DC, Abstract 1120, Jul. 2000.
Habeck, M. “Infectious Link to Alzheimer's Disease,” Targets, vol. 1, No. 5, p. 147, Dec. 2002.
Mahony, J. et al. “Chlamydia Pneumoniae in the Alzheimer's Brain—Is DNA Detection Hampered by Low Copy Number?,” Proceedings Fourth Meeting of the European Society for Chlamydia Research, Helsinki-Finland, Clinical Diseases, p. 275, Aug. 2000.
Ossewaarde, J.M., et al. “Chlamydia Pneumoniae Antigens Are Present in the Brains of Alzheimer Patients, But Not in the Brains of Patients with Other Dementia's” Proceedings Fourth Meeting of the European Society for Chlamydia Research, Helsinki-Finland, Clinical Diseases, p. 284, Aug. 2000.
Abrams J. Todd
Balin Brian J.
Hudson Alan P.
Whittum-Hudson Judith A.
Caesar Rivise Bernstein Cohen & Pokotilow Ltd.
Intracell, LLC
Peselev Elli
LandOfFree
Treatment and diagnosis of alzheimer's disease does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Treatment and diagnosis of alzheimer's disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment and diagnosis of alzheimer's disease will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3783210