Treating vascular and neoplastic tissues

Details Treating vascular and neoplastic tissues Treating vascular and neoplastic tissues

1995-03-21

1996-11-19

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424427, 424443, 424445, 424449, A61F 202, A61K 970, A61L 1516

Patent

active

055760139

ABSTRACT:
Lesions supplied by abnormal aggregations of vascular tissue or neovascular tissues are treated with photodynamic therapy by application of photosensitizing agent followed by precisely directed and calibrated laser activation to induce photothrombosis within target vascular tissue. The treatment forms a blood clot within the supply vessels thereby reducing the blood supply to the target lesion. Treated tissues atrophy or recede with low regrowth of vessels. The lower energy levels required significantly reduce damage to the surrounding tissues.

REFERENCES:
patent: 4932934 (1990-06-01), Dougherty et al.
patent: 5279298 (1994-01-01), Flower
Roberts et al., "Role of neovasulature and vascular permeability on tumor retention of photodynamic agents", Cancer Res (1992), 52(4), 924-30 (Abstract only).
Mendelsohn et al., "Ameleriotion . . . by photochemical induced thrombosis of feeder vessels," Arch of Ophthalmol. (Chicago) 1987, 105(7), 983-8 (Abstract only).

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