Treating/preventing heart failure via inhibition of mast cell de

Details Treating/preventing heart failure via inhibition of mast cell de Treating/preventing heart failure via inhibition of mast cell de

1999-08-17

2000-10-31

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 314535

Patent

active

061403482

ABSTRACT:
Heart failure is treated/prevented by administering to candidate subjects the inhibitor of mast cell degranulation ketotifen to prevent adverse myocardial remodeling secondary to a sustained blood volume overload.

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Berges et al., Intensivmedizin, 18/4, (229-231) (abstract), 1981.
Kovanen et al, Circulation, vol. 92, pp. 1084-1088 (1995).
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