Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ketone doai
Patent
1995-04-10
1997-02-18
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ketone doai
A61K 3112
Patent
active
056042639
ABSTRACT:
A pharmaceutical composition for treating osteoporosis which comprises as an active ingredient an effective amount of one or more compounds selected from the-group comprising humulone, cohumulone, adhumulone, isohumulone, isocohumulone and isoadhumulone in combination with a pharmaceutically acceptable carrier or excipient. Humulone, cohumulone, adhumulone are the compounds belonging to .alpha. acids which are an ingredient extracted from hops, whilst isohumulone, isocohumulone and isoadhumulone are the compounds belonging to iso .alpha. acid derivatives which are isomers of .alpha. acids.
The above described compounds have a bone resorption inhibiting activity and are useful for treating osteoporosis.
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Yoshikawa et al., "Roles of Osteoblasts in Bone Remodeling," Journal of Clinical and Experimental Medicine 165 (9):568-71 (1993) (with English translation).
Mizobuchi et al., "Antifungal Activities of Hop Bitter Resins and Related Compounds," Agric. Biol Chem. 49(2):399-403 (1985).
Anteunis et al., "The Complex of Humulone and 1,2-Diaminobenzene," Bull. Soc. Chim. Belg. 72:60-68 (1963).
Obara et al., "A Synthetic Route to (+/-)-Humulone," Bull. Chem. Soc. Jpn. 62(9):3034-35 (1989).
Alderweireldt et al., "Nuclear Magnetic Resonance Spectroscopy and the Analysis of the Alpha Acids of Hops," Wallerstein Communications 27(92):19-28 (1964).
Tagashira Motoyuki "Utilization of Humulones Having Antioxidant Action," Patent Abstracts of Japan vol. 94, No. 011 and JP-A-06 312924 (Asahi Breweries Ltd.) (Aug. 11, 1994).
Kitamura Kazuyuki
Tobe Hiroyasu
Criares Theodore J.
Hoechst Japan Limited
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