Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution...
Reexamination Certificate
2001-09-06
2003-06-10
Lankford, Jr., Leon B. (Department: 1651)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
C424S777000, C424S730000, C424S765000, C424S738000, C424S764000, C424S735000, C424S757000
Reexamination Certificate
active
06576269
ABSTRACT:
BACKGROUND OF THE INVENTION
This invention relates to a method of extracting compounds from sea buckthorn, to compositions containing that extract, and to the use of those compositions to treat open skin lesions. In particular, it relates to extracting sea buckthorn in vegetable oil in the absence of metals and oxygen.
In 1998 there were over 33 million office visits to dermatologists in the United States, many due to open skin lesions. Elderly people, especially those in nursing facilities, are susceptable to open sores, also called bed sores, pressure ulcers, or decubitus ulcers, and there are an estimated three million pressure sores in the United States each year. For the past several decades, tens of billions of dollars have been spend caring for patients with pressure sores. Despite all of the knowledge generated, the treatment of pressure sores still requires several months, and they frequently become one of the main factors complicating a patient's life. One of the main functions of the skin is forming a barrier between the organism and the environment. Pressure sores and ulcers disrupt the integrity of the skin and open the gates for the bacterial penetration, leading to secondary infections and reducing life expectancy.
Bedsores are usually caused by reduced blood circulation in limited skin areas. Skin ulcers may be induced by long-term treatment with high doses of steroid hormones and occur as one of the side effects of chemotherapy and radiotherapy. Skin ulcers are one of serious complications of diabetes.
While primary damage may be inflicted by different causes, the healing of skin ulcers, traumatic wounds, burns and other open skin wounds and injuries usually undergo similar sequence of steps that results in restoration of structural integrity of the skin. These steps include wound cleansing, achieved through the influx of inflammatory cell, proliferation of stromal cells to initiate the restorative processes and ingrowth of blood vessels to provide nutritional support for the regeneration. Effective treatment may be expected to promote wound healing through the support of these steps and protection of the area of open injury against bacterial infection and dehydration.
Treatment of open skin sores in elderly patient is further complicated by the reduced rate of regenerative processes, decreased immune system activity, and increased sensitivity to antibiotic therapy. Therefore, topical preparations able to stimulate the regenerating ability of the skin and promote the healing process may assist the healing pressure sores, reduce the probability of secondary infections and improving the quality of patients life overall.
In spite of considerable advances in recent years in the treatment of burns and wounds, the occurrence of bedsores or decubitus ulcers continues to grow. Increases in the number of patients with restricted mobility, which most frequently suffer from bad sores and have the longest recovery period calls for the introduction of new, more efficient, and safe treatments. There are many different products available for the treatment of decubitus ulcers, mostly addressing the issues of prevention and elimination of the bacterial infection and protection against dehydration. Medications with potent antibacterial agents, such as antibiotics, iodine derivatives, hydrogen peroxide, boric acid derivatives etc. are good in protecting against infection, but the occurrence of allergic reactions and skin irritations to these agents may further reduce the rate of skin regeneration, increasing the recovery time, especially in the elderly patients. Medications, comprising synthetic antibacterial agent, hormones, or hormone derivatives, often induce skin sensitization during repetitive applications, usually required for successful treatment of decubitus ulcers. Administration of such medications on the daily basis may cause increasing skin irritation and inflammatory response, especially in elderly patients, interfering with the healing process.
It is a principal object of the present invention to overcome these disadvantages and provide a novel composition suitable for the treatment of open skin lesions, including bedsores or decubitus ulcers.
SUMMARY OF THE INVENTION
I have discovered that vegetable oil extracts of sea buckthorn, made in the absence of metals and oxygen, are superior to the same extracts made in the presence of metals or oxygen. Compositions made from the extract not only stimulate and provide the nutrients required for the proliferation of epithelial cells, but also protect the injured area against bacterial infections and dehydration over the course of treatment.
The present invention relates to the method and the compositions for the treatment of skin lesions, such as pressure sores or decubitus ulcers, heat burns, radiation and chemical burns, poor healing wounds and skin damages inflicted by laser or radiation therapy. The composition comprises liposoluble ingredients of sea buckthorn that provide nutrient and increases viability of regenerating cells. The composition may further include a combination of essential oils and herbal extracts, which stimulate regeneration of epidermal cells and have antibacterial properties. The composition is applied topically to the injured skin areas and as a result or repetitive administrations induces and stimulates restorative processes and promotes regeneration of the skin.
The present invention is related to the field of medical treatment of skin conditions, more specifically to a novel composition useful for the treatment and promotion of regeneration of open skin lesions. In particular but not exclusively the invention relates to compositions comprising liposoluble extract of sea buckthorn and its use in the treatment of pressure sores or decubitus ulcers and burns.
In brief, the composition according to the present invention is useful in the treatment of various open lesions of the skin, including open wounds, ulcers, burns, skin damages inflicted by radiation therapy or laser surgery, and in particular the composition is useful in the treatment of bedsores or decubitus ulcers. The composition is formulated as an ointment or lotion and is applied to the site of injury on the regular basis until the integrity of the skin surface is reconstituted. The composition includes liposoluble herbal extracts, essential oils, antioxidant, and vegetable oils. The liposoluble herbal extracts are present in the composition in the amount, which is effective to promote the regeneration of skin cells and provide nutritional support required for epithelial cell regeneration. Essential oils are included in the composition in the amount sufficient to stimulate cell regeneration and provide antibacterial action. Antioxidant is added to increase the stability of the composition and as a source of nutrients for regenerating skin cells. Vegetable oils are used a carrier or diluent and also protect the area of open skin injury against dehydration.
Another main object of this invention is to make available a novel composition useful in the continued and long-term treatment of bedsores or decubitus ulcers without skin sensitization, irritation or induction of adverse reactions of the skin.
A further objective of this invention is to provide a novel composition for the treatment of open skin lesions that stimulates tissue regeneration and promotes the restoration of skin integrity.
Other objective of the present invention is to provide a novel composition combining restorative action with protection against dehydration, and antiseptic effect.
Yet another objective of the present invention is to provide a method for the preparation of the composition for the treatment of open skin lesions.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
In this invention an extract is made of the herb, sea buckthorn (
Hippophae rhamnoides
). A composition is made that includes the extract and the composition is used topically to treat open skin lesions.
Extraction
An extract is prepared of the berries of sea buckthorn using a vegetable oil as the so
Davis Ruth
Fuerle Richard D.
Lankford , Jr. Leon B.
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