Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Reexamination Certificate
2006-01-05
2010-06-01
Chong, Yong S (Department: 1627)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C514S510000, C514S613000, C514S675000, C514S678000, C514S679000, C514S680000
Reexamination Certificate
active
07728034
ABSTRACT:
The present invention provides methods of treating neurological disorders in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transient sodium current.
REFERENCES:
patent: 5661035 (1997-08-01), Tsien et al.
patent: 5688830 (1997-11-01), Berger et al.
patent: 5922746 (1999-07-01), Adorante
patent: 6342379 (2002-01-01), Tsien et al.
patent: 6479498 (2002-11-01), Marquess et al.
patent: 6646012 (2003-11-01), Choi et al.
patent: 6686193 (2004-02-01), Maher et al.
patent: 6699493 (2004-03-01), Wong
patent: 6726918 (2004-04-01), Wong et al.
patent: 6756400 (2004-06-01), Chinn et al.
patent: 2002/0077297 (2002-06-01), Adorante et al.
patent: 2004/0054374 (2004-03-01), Weber et al.
patent: 2004/0137059 (2004-07-01), Nivaggioli et al.
patent: 1 182 193 (2002-02-01), None
Agrawal, Newton et al.,Increased Persistent Sodium Currents in Rat Entorhinal Cortex Layer V Neurons in a Post-Status Epilepticus Model of Temporal Lobe Epilepsy, 44(12) Epilepsia 1601-1604 (2003).
Ahern, Gerard P. et al.,Induction of Persistent Sodium Current by Exogenous and Endogenous Nitric Oxide, 275(37) J. Biol. Chem. 28810-28815 (2000).
Anger, Thorsten et al.,Medicinal Chemistry of Neuronal Voltage-Gated Sodium Channel Blockers, 44(2) J. Med. Chem. 115-137 (2001).
Barbato, Joel E. & Edith Tzeng,Nitric Oxide and Arterial Disease40(1) J. Vasc. Surg. 187-193 (2004).
Barber, Alistair J.,A New View of Diabetic Retinopathy: A Neurodegenerative Disease of the Eye, 27(2) Prog. Neuropsychopharmacol. Biol. Psychiatry. 283-290 (2003).
Barnham, Kevin J. et al.,Neurogegenerative diseases and Oxidative Stress, 3(3) Nat. Rev. Drug. Dis. 205-214 (2004).
Bass, B. L.,RNA Interference. The Short Answer, 411(6836) Nature 428-429 (2001).
Bolanos, Juan P. & Angeles Almeida,Roles of Nitric Oxide in Brain Hypoxia-Ischemia, 1411(2-3) Biochim. Biophys. Acta. 415-436 (1999).
Bonanni, Paolo et al.,Generalized Epilepsy with Febrile Seizures Plus(GEFS+):Clinical Spectrum in Seven Italian Families Unrelated to SCN1A, SCN1B, and GABRG2 Gene Mutations, 45(2) Epilepsia 149-158 (2004).
Brismar, Tom,Abnormal Na-Currents in Diabetic Rat Nerve Nodal Membrane, 10(Suppl. 2) Diabet. Med. 110S-112S (1993).
Broadbent, H. Smith et al.,Quinoxalines. I. Preparation and Stereochemistry of Decahydroquinoxalines, 82(1) J. Amer. Chem. Soc. 189-193 (1960).
Catterall, William A.,From Ionic Currents to Molecular Mechanism: The Structure and Function of Voltage-gated Sodium Channels, 26(1) Neuron 13-25 (2000).
Ceulemans, Berten P. G. M. et al.,Clinical Correlations of Mutations in the SCN1A Gene: from Febrile Seizures to Severe Myoclonic Epilepsy in Infancy, 30(4) Pediatr. Neurol. 236-243 (2004).
Craner, Matthew J. et al.,Co-Localization of Sodium Channel Nav1.6 and the Sodium-Calcium Exchanger at Sites of Axonal Injury in the Spinal Cord in EAE, 127(2) Brain 294-303 (2004).
Craner, Matthew J. et al.,Molecular Changes in Neurons in Multiple Sclerosis: Altered Axonal Expression of Nav1.2 and Nav1.6 Sodium Channels and Na+/Ca2+ Exchanger, 101(21) Proc. Natl. Acad. Sci. U.S.A. 8168-8173 (2004).
Crill, Wayne E.,Persistent Sodium Current in Mammalian Central Neurons58 Annu. Rev. Physiol. 349-362 (1996).
Current Protocols in Molecular Biology (Frederick M. Ausubel et al., eds., John Wiley & Sons, 2004).
Do, Michael Tri H. & Bruce P. Bean,Subthreshold Sodium Currents and Pacemaking of Subthalamic Neurons: Modulation by Slow Inactivation, 39(1) Neuron 109-120 (2003).
Elbashir, Sayda M. et al.,Duplexes of 21—nucleotide RNAs Mediate RNA Interference in Cultured Mammalian Cells, 411(6836) Nature 494-498 (2001).
Fukuma, Goryu et al.,Mutations of Neuronal Voltage-Gated Na+ Channel Alpha 1 Subunit Gene SCN1A in Core Severe Myoclonic Epilepsy in Infancy(SMEI)and in Borderline SMEI(SMEB), 45(2) Epilepsia 140-148 (2004).
Gardner, Thomas W. et al.,Diabetic Retinopathy: More than Meets the Eye, 47(Suppl. 2) Surv. Ophthalmol. S253-S262 (2002).
Garthwaite, Gita et al.,Mechanisms of Ischaemic Damage to Central White Matter Axons: A Quantitative Histological Analysis Using Rat Optic Nerve, 94(4) Neuroscience 1219-1230 (1999).
Garthwaite, Gita et al.,Nitric Oxide Toxicity in CNS White Matter: An in Vitro Study Using Rat Optic Nerve, 109(1) Neuroscience 145-155 (2002a).
Garthwaite, Gita et al.,Soluble Guanylyl Cyclase Activator YC-1 Protects White Matter Axons From Nitric Oxide Toxicity and Metabolic Stress, Probably Through Na(+)Channel Inhibition, 61(1) Mol. Pharmacol. 97-104 (2002b).
GenBank database (National Institutes of Health, National Library of Medicine, http://www.ncbi.nlm.nih.gov/).
Ghofrani, Hossein A. et al.,Nitric Oxide Pathway and Phosphodiesterase Inhibitors in Pulmonary Arterial Hypertension, 43(12 Suppl. S) J. Am. Coll. Cardiol. 68S-72S (2004).
Goldin, Alan L.,Diversity of Mammalian Voltage-gated Sodium Channels, 868 Ann. N.Y. Acad. Sci. 38-50 (1999).
Gonzalez, Jesus E. & Michael P. Maher,Cellular Fluorescent Indicators and Voltage/Ion Probe Reader(VIPR)Tools for Ion Channel and Receptor Drug Discovery, 8(5-6) Receptors Channels 283-295, (2002).
Gonzalez, Jesus E. & Roger Y. Tsien,Improved Indicators of Cell Membrane Potential That Use Fluorescence Resonance Energy Transfer4(4) Chem. Biol. 269-277 (1997).
Goodman & Gilman's The Pharmacological Basis of Therapeutics (Joel G. Hardman et al., eds., McGraw-Hill Professional, 10thed. 2001).
Hammarström, Anna H. K. & Peter W. Gage,Oxygen-sensing Persistent Sodium Channels in Rat Hippocampus, 529(1) J. Physiol. 107-118 (2000).
Hammarström, Anna K. M. & Peter W. Gage,Hypoxia and Persistent Current, 31 (3) Eur. Biophys. J. 323-330 (2002).
Hammarström, Anna K. M. & Peter W. Gage,Nitric Oxide Increases Persistent Sodium Current in Rat Hippocampal Neurons, 520(2) J. Physiol. 451-461 (1999).
Handbook of Pharmaceutical Excipients (Raymond C. Rowe et al., APhA Publications, 4thedition 2003).
Heller,Biodegradable Polymers in Controlled Drug Delivery(CRC Critical Reviews in Therapeutic Drug Carrier Systems, vol. 1. CRC Press, 1987).
Imaging Neurons: A Laboratory Manual (Rafael Yuste, et al., eds., Cold Spring Harbor Laboratory Press, 2000).
Jayasena, Sumedha D.,Aptamers: An Emerging Class of Molecules That Rival Antibodies in Diagnostics, 45(9) Clin. Chem. 1628-1650 (1999).
Johnson, Iain D.,Fluorescent Probes for Living Cells30(3) Histochem. J. 123-140 (1998).
Ju, Yue-Kun et al.,Hypoxia Increases Persistent Sodium Current in Rat Ventricular Myocytes, 497(2) J. Physiol. 337-347 (1996).
Kamiya, Kazusaku et al.,A Nonsense Mutation of the Sodium Channel Gene SCN2A in a Patient with Intractable Epilepsy and Mental Decline, 24(11) J. Neurosci. 2690-2698 (2004).
Karabinos, Anton et al.,Essential Roles for Four Cytoplasmic Intermediate Filament Proteins in Caenorhabditis elegans Development, 98(14) Proc. Natl. Acad. Sci. USA 7863-7868 (2001).
Klein, Joshua P. et al.,Dysregulation of Sodium Channel Expression in Cortical Neurons in a Rodent Model of Absence Epilepsy, 1000(1-2) Brain Res. 102-109 (2004).
Kohling, Rudiger,Voltage-gated Sodium Channels in Epilepsy, 43(11) Epilepsia 1278-1295 (2002).
Lieth, Erich et al.,Retinal Neurodegeneration: Early Pathology in Diabetes, 28(1) Clin. Experiment. Ophthalmol. 3-8 (2000).
Lipton, Peter,Ischemic Cell Death in Brain Neurons, 79(4) Physiol. Rev. 1431-1568 (1999).
Lossin, Christoph et al.,Molecular Basis of an Inherited Epilepsy34(6) Neuron 877-84 (2002).
Magistretti, Jacopo & Angel Alonso,Biophysical Properties and Slow-voltage Dependent Inactivation of a Sustained Sodium Current in Entorhinal Cortex Layer-II Principal Neurons: A Whole-Cell and Single-Channel Study114(4) J. Gen. Physiol. 491-509 (1999).
Maier, Sebastian K. G. et al.,An Unexpected Requirement for Brain-Type Sodium Channels for Control of Heart Rate in the Mouse Sinoatrial Node, 100(6) Proc. Natl. Acad. Sci. U. S. A. 3507-3512 (2003).
Maier. Sebastian K. G. et al.,Distinct Subcellular Localization of Different Sodium Chan
Adorante Joseph S.
Ehring George R.
Malone Thomas
Wheeler Larry A.
Whitcup Scott M.
Allergan Inc.
Allergan, Inc.
Chong Yong S
German Joel B.
Stathakis Dean G.
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