Treating inflammation with hepatocyte stimulating factor interfe

Details Treating inflammation with hepatocyte stimulating factor interfe Treating inflammation with hepatocyte stimulating factor interfe

1987-07-20

1990-11-27

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

424 852, 435 6951, 435 6952, 514 12, 514 21, 514893, A61K 3766, A61K 4505, A61K 3700, C12P 2106

Patent

active

049734784

ABSTRACT:
Interferon .beta..sub.2 has been identified as the major factor responsible for stimulating hepatocytes to produce anti-inflammatory agents. A method for its use in so stimulating hepatocytes is described herein.

REFERENCES:
patent: 4606917 (1986-08-01), Eppstein
Taniguchi, M. Chem. Abstr., vol. 106, Abstract No. 107907k, 1987.
Koj, A. et al., Biochem. J. vol. 224, pp. 505-514, (1984).
Gauldie et al., "Interferon .beta..sub.2 /B-cell . . . "Proc. Natl Acad. Sci., vol. 84, pp. 7251-7255, Oct. 1987.
Andus et al., "Recombinant Human B cell . . . "FEBS Letter, vol. 221, No. 1, pp. 18-22, Aug. 1987.
Patent Abstrcts of Japan, vol. 10 No. 198, 11 Jul. 1986 & JPA-61 40 568, (Kyowa Hakko Kogyo Co. Ltd.) 26-02-1986.
Michel Revel, et al., "Autocrine Interferons and Interferon-.beta..sub.2 ", Jour. of Interferon Research, 7:529-536 (1987).
S. Marinkovic et al., "IL-6 Modulates the Synthesis of a Specific Set of Acute Phase . . . ", J. Immunol. Vol. 142, No. 3, 1989: 808-812.
Zilberstein, A. et al., "Structure & Expression of cDNA and Genes for Human Interferon . . . ", The EMBO Journal vol. 5, No. 10, pp. 2529-2537, 1986.

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