Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1995-06-30
1997-12-09
Lankford, Jr., Leon B.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
424 946, 424 941, 435196, 435200, A61K 3847, A61K 3846, A61K 3843, C12N 924
Patent
active
056957521
ABSTRACT:
Compositions are administered to a patient (preferably by injection and locally) to treat a variety of conditions including inflammation associated with trauma and with certain aspects of diseases such as rheumatoid arthritis, psoriasis, insulin-dependent diabetes, cutaneous lymphomas, duodenal ulcer, chronic proctitis, lymphocytic thyroidiris, hemorphagic shock, reperfusion injury during transplantation and multiple sclerosis. The compositions are pharmaceutically acceptable injectable formulations which include an active component in a pharmaceutically acceptable carrier. The active component is a chlorate or selenate which inhibits the natural biochemical sulfation process and/or a sulfatase enzyme which removes a sulfate from a specific position of a saccharide molecule which makes up a part of a natural ligand for L-selectin. Removal of the sulfate from the ligand hinders the ability of the ligand to bind to its natural receptor (i.e. L-selectin) and thereby hinders a biochemical chain of events which results in inflammation.
REFERENCES:
patent: 4163783 (1979-08-01), Klein et al.
patent: 4370325 (1983-01-01), Packman
patent: 4849513 (1989-07-01), Smith et al.
patent: 5013724 (1991-05-01), Petitou et al.
patent: 5143172 (1992-09-01), Brandley et al.
Roberton et al, Biochem. J. 293:683-689 (1993).
Tomatsu et al, Biochem. Biophys. Res. Comm. 181(2):677-683 (1991).
Robertson et al, Biochem. Biophys. Res. Comm. 157(1): 218-224 (1988).
Glabe et al., "Preparation and Properties of Fluorescent Polysaccharides", Anal. Biochem., 130:287-294 (1983).
Kishimoto et al., "Identification of a human peripheral lymph node homing receptor: A rapidly down-regulated adhesion molecule", Proc. Natl. Acad. Sci. USA, 87:2244-2248 (1990).
Lasky, L.A., "Lectin Cell Adhesion Molecules (LEC-CAMs): A New Family of Cell Adhesion Proteins Involved With Inflammation", J. Cell Biochem., 45:139-146 (1991).
Rosen et al., "L-Selectin: A Lectin-Like Leukocyte Adhesion Protein", Trends in Glycoscience and Glycotechnology, 4:1-13 (1992).
Springer, T., "Adhesion Receptors of the Immune System", Nature, 346:425-434 (1990).
Stoolman et al., "Phosphomannosyl Receptors May Participate in the Adhesion Interaction between Lymphocytes and High Endothelial Venules", J. Cell Biol., 99:1535-1540 (1984).
Willenborg et al., "Phosphosugars are potent inhibitors of central nervous system inflammation", Faseb. J., 3:1968-1971 (1989).
Willenborg et al., "Inhibition of Allergic Encephalomyeltis in Rats by Treatment With Sulfated Polysaccharides", J. Immunol., 140:3401-3405 (1988).
Brandley, et al., "Cell-Surface Carbohydrates in Cell Recognition and Response," J. Leuk. Biol., (1986) 40:97-111.
Sharon, et al., "Lectins as Cell Recognition Molecules," Science, (1989) 246:227-234.
Dodd, et al., "Lactoseries Carbohydrates Specify Subsets of Dorsal Root Ganglion Neurons Projecting to the Superficial Dorsal Horn of Rat Spinal Cord," J. Neurosci., (1985) 5(12):3278-3294.
Regan, et al., "Selective Expression of Endogenous Lactose-binding Lectins and Lactoseries Glycoconjugates in Subsets of Rat Sensory Neurons," Proc. Natl. Acad. Sci. USA, (1986) 83:2248-2252.
Constantine-Paton, et al., "A Cell Surface Molecule Distributed in a Dorsoventral Gradient in the Perinatal Rat Retina," Nature, (1986) 324:459-462.
Tiemeyer, et al., "Ganglioside-specific Binding Protein on Rat Brain Membranes," J. Bio. Chem., (1989) 264(3):1671-1681.
Bevilacqua, et al., "Identification of an Inducible Endothelial-Leukocyte Adhesion Molecule," Proc. Natl. Acad. Sci. USA, (1987) 84:9238-9242.
Fukuda, et al., "Structure of a Novel Sialylated Fucosyl Lacto-N-nor-hexaosylceramide Isolated from Chronic Myelogenous Leukemia Cells," J. Biol. Chem., (1986) 261(5):2376-2383.
Magnani, et al., "A Monoclonal Antibody-defined Antigen Associated with Gastrointestinal Cancer is a Ganglioside Containing Sialylated Lacto-N-fucopentaose II," J. Biol. Chem., (1982) 257(23):14365-14369.
Hakomori, et al., "Human Cancer-Associated Gangliosides Defined by a Monoclonal Antibody (IB9) Directed to Sialosyl.alpha.2.fwdarw.6 Galactosyl Residue: A Preliminary Note," Biochem. and Biophys. Res. Comm., (1983) 113(3):791-798.
Fukushi, et al., "Localization and Alteration of Mono-, Dl-, and Trifucosyl .alpha.1.fwdarw.3 Type 2 Chain Structures During Human Embryogenesis and in Human Cancer," J. Exp. Med., (1984) 159:506-520.
Geng, et al., "Rapid Neutrophil Adhesion to Activated Endothelium Mediated by GMP-140," Nature, (1990) 343:757-760.
Johnston, et al., "Cloning of GMP-140, a Granule Membrane Protein of Platelets and Endothelium: Sequence Similarity to Proteins Involved in Cell Adhesion and Inflammation," Cell, (1989) 56:1033-1044.
Geoffroy, et al., "Demonstration that a Lectin-like Receptor (gp90.sup.MEL) Directly Mediates Adhesion of Lymphocytes to High Endothelial Venules of Lymph Nodes," J. Cell Biol., (1989) 109:2463-2469.
Lasky, et al., "Cloning of a Lymphocyte Homing Receptor Reveals a Lectin Domain," Cell, (1989) 56:1045-1055.
Bevilacqua, et al., "Endothelial Leukocyte Adhesion Molecule 1: An Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins," Science, (1989) 243:1160-1165.
Watson, et al., "Neutrophil Influx into an Inflammatory Site Inhibited by a Soluble Homing Receptor-IgG Chimaera," Nature, (1991) 349:164-167.
Spertini, et al., "Regulation of Leukocyte Migration by Activation of the Leukocyte Adhesion Molecule-1 (LAM-1) Selectin," Nature, (1991) 349:691-694.
Imai, et al., "Direct Demonstration of the Lectin Activity of gp90.sup.MEL, a Lymphocyte Homing Receptor," J. Cell Biol., (1990) 111:1225-1232.
Imai, et al., "Identification of a Carbohydrate-based Endothelial Ligand for a Lymphocyte Homing Receptor," J. Cell Biol., (1991) 113(5):1213-1221.
Lerouge, et al., "Symbiotic Host-specificity of Rhizobium meliloti is Determined by a Sulphated and Acylated Glucosamine Oligosaccharide Signal," Nature, (1990) 344:781-784.
Fiete, et al., "A Hepatic Reticuloendothelial Cell Receptor Specific for SO.sub.4 -4GalNAc.beta.1,4GlcNAc.beta.1,2Man.alpha. That Mediates Rapid Clearance of Lutropin," Cell, (1991) 67:1103-1110.
Baeuerle, et al., "Chlorate-A Potent Inhibitor of Protein Sulfation in Intact Cells," Biochem. and Biophys. Res. Comm., (1986) 141(2):870-877.
Gallatin, et al., "A Cell-Surface Molecule Involved in Organ-Specific Homing of Lymphocytes," Nature, (1983) 304:30-34.
Stoolman, "Adhesion Molecules Controlling Lymphocyte Migration," Cell, (1989) 56:907-910.
Yednock, et al., "Phosphomannosyl-derivatized Beads Detect a Receptor Involved in Lymphocyte Homing," J. Cell Biol., (1987) 104:713-723.
Yednock, et al., "Receptors Involved in Lymphocyte Homing: Relationship Between a Carbohydrate-binding Receptor and the MEL-14 Antigen," J. Cell Biol., (1987) 104:725-731.
Bevilacqua, et al., "Selectins: A Family of Adhesion Receptors." Cell, (1991) 67:233.
Lasky, et al., "An Endothelial Ligand for L-Selectin Is A Novel Mucin-like Molecule," Cell, (1992) 69:927-938.
Rosen, et al., "Involvement of Sialic Acid on Endothelial Cells in Organ-Specific Lymphocyte Recirculation," Science, (1985) 228:1005-1007.
Imai, et al., "Further Characterization of the Interaction Between L-selectin and its Endothelial Ligands," Glycobiology, (1992) 2(4):373-381.
Siegelman, et al., "Mouse Lymph Node Homing Receptor cDNA Clone Encodes a Glycoprotein Revealing Tandem Interaction Domains," Science, (1989) 243:1165-1172.
Tedder, et al., "Isolation and Chromosomal Localization of cDNAs Encoding a Noval Human Lymphocyte Cell Surface Molecule, LAM-1," J. Exp. Med., (1989) 170:123-133.
Camerini, et al., "Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor," Nature, (1989) 342:78-82.
Stoolman, et al., "Possible Role for Cell-surface Carbohydrate-binding Molecules in Lymphocyte Recirculation," J. Cell Biol., (1983) 96:722-729.
Berg, et al., "The Human Peripheral Lymph Node Vascular Addressin is a Ligand for LECAM-1, the Peripheral Lymph Node Homing Receptor," J. Cell Biol., (1991) 114(2):343-349.
Streeter, et al., "Immunohistologic and Functional Characterization of
Hemmerich Stefan
Imai Yasuyuki
Rosen Steven D.
Bozicevic Karl
Field Bret
Lankford , Jr. Leon B.
Prats Francisco C.
The Regents of the University of California
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