Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1975-02-12
1977-02-01
Rosen, Sam
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
A61K 31505
Patent
active
040062350
ABSTRACT:
Method and pharmaceutical preparations for treating meningeal leukemia, CNS lymphoma and neoplasms in the brain which comprises treating an infected mammal such as a human with a dose of an effective treatment amount of a compound of Formula I ##STR1## where R is a straight or branched chain lower alkyl of 1 to 4 carbon atoms, and X is a halogen atom (fluorine, chlorine, bromine or iodine) and pharmaceutically acceptable salts thereof.
Preferred compounds for treatment of the aforementioned diseases are 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methyl-pyrimidine and 2,4-diamino-5-(3',4'-dichlorophenyl)-6-ethyl-pyrimidine.
REFERENCES:
murphy et al.--J. Clin. Invest.--vol. 33, (1954), p. 1388 et seq.
Geils et al.--Blood--vol. 38, No. 2, (1971), pp. 131-137.
Elion Gertrude B.
Hitchings George H.
Nichol Charles A.
Simmons William S.
Stickney Dwight R.
Burroughs Wellcome Co.
Rosen Sam
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