Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-02-04
1995-04-18
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31415
Patent
active
054079535
ABSTRACT:
This invention provides a method for treating sleep apnea, hypopnea and/or snoring in a human patient by administering to said patient a compound that results in the release of pilocarpine to the nasopharnyx and hypopharnyx tissues an amount effective to reduce or eliminate such sleep apnea, hypopnea and snoring condition in such patient.
Pilocarpine hydrochloride and pilocarpine nitrate in sustained release ocular compositions are preferred for convenience but other forms such as eye-drop solutions or aqueous gel forms may also be used. Pro-drug or targeted drug forms of pilocarpine that result in more effective tissue absorption and subsequent release of the pharmacologically active pilocarpine may also be utilized.
REFERENCES:
Ehmbace abstract of Chessen et al. Dis. Nerv. Syst. 35(4): 152-153 (1974) "ECT, Glaucoma, and Prolonged Apnea".
D. H. Chessen, et al, Diseases of the Nervous System, vol. 35, No.4, Apr., 1974, pp. 152-152, "ECT . . . Prolonged Apnea".
Goldstein, A., et al, Princ. of Drug Action, 2nd Ed., 1968 pp. 140-141, (re fatal apnea).
C&E NEWS, Sep. 6, 1971, pp. 20, 22; (re ALZA, Ocusert.TM.).
Weinstein Modern Medicine, Oct.30-Nov. 15, 1978, pp. 26-33. (re sleep disorders.
Lange's BASIC . . . Pharmacology, 3rd Edit., 1987, pp. 64-68. (re cholinoceptor stimulants).
PDR, 17th Edit., 1989, for Opthalmology, p. 105. (re ALZA's OCUSERT.TM. pilocarpine).
Korolkovas, A., Essentials of Med. Chem., 2nd Edit., 1988, pp. 114-117 (re pilocarpine esters).
Young et al., The New England J. of Medicine, Apr. 29, 1993, pp. 1230-1235, (re sleep disorders).
PDR (for Opthalmology), 1993, p. 3, (re MIOTICS including pilocarpine salts).
Medline Express.TM. computer search report, 6 pp., re terms "Apnea", Sleep Apnea syndromes done in 1993-1994.
Reynolds John T.
Rose Shep K.
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