Treating anxiety with certain ring-fused pyrazolo[3,4-d]-pyridin

Details Treating anxiety with certain ring-fused pyrazolo[3,4-d]-pyridin Treating anxiety with certain ring-fused pyrazolo[3,4-d]-pyridin

1986-11-21

1988-04-26

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 82, A61K 3144, C07D47104

Patent

active

047405120

ABSTRACT:
Compounds of the formula IA or IB ##STR1## wherein A represents an optionally substituted saturated divalent grouping which together with the two carbon atoms to which it is attached represents a fused 5-, 6- or 7-membered carbocyclic or heterocyclic ring selected from optionally substituted fused cyclopenteno, cyclohexeno, cyclohepteno, dihydrothieno, dihydrothiopyrano, tetrahydrothiepino, dihydrofuro, dihydropyrano, tetrahydrooxepino, dihydropyrrolo, tetrahydropyrido and tetrahydroazepino; R.sub.1 represents lower alkyl, phenyl, or phenyl mono- or disubstituted by lower alkyl, lower alkoxy, halogen or trifluoromethyl; or R.sub.1 represents an aromatic heterocyclic radical selected from e.g. optionally substituted pyridyl, quinolyl, isoquinolyl, pyrimidyl and thiazolyl; R.sub.2, R.sub.3, R.sub.3 ' are hydrogen or lower alkyl; and pharmaceutically acceptable salts; are useful as benzodiazepine receptor modulators for the treatment of nervous system disorders. Pharmaceutical compositions, methods of preparation and certain intermediates useful as benzodiazepine receptor modulators are also disclosed.

REFERENCES:
patent: 4602014 (1986-07-01), Yokoyama
patent: 4647566 (1987-03-01), Yokoyama
The Pharmacologist, 28, 112, (1986), Abstract No. 116.
Poster entitled "CGS 17867A: A Non-Sedating Benzodiazepine Agonist", presented-Aug. 18, 1986, American Society for Pharmacology and Experimental Therapeutics and Society of Toxicology Joint Meeting, Baltimore, Md.

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