Treating abdominal pain due to pancreatitis with seaprose

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07459155

ABSTRACT:
This invention relates to methods for maintaining the basal level or reducing the level of cholecystokinin (CCK) in blood plasma of a mammal. Additionally, the invention provides methods for treating pain in a mammal and more particularly, methods for treating abdominal pain in a mammal. The methods include administering to the mammal a non-pancreatic protease or a composition comprising a non-pancreatic protease. The methods of this invention are particularly useful for treating abdominal pain in a mammal suffering from acute or chronic pancreatitis and related conditions.

REFERENCES:
patent: 4485095 (1984-11-01), Fujisaki et al.
patent: 4755383 (1988-07-01), Fujii et al.
patent: 5514373 (1996-05-01), Harris, Jr.
patent: 6413512 (2002-07-01), Houston et al.
patent: 2001/0006617 (2001-07-01), Liversidge et al.
patent: 2003/0026794 (2003-02-01), Fein
patent: 2003/0143292 (2003-07-01), Cho
patent: 2004/0038874 (2004-02-01), Omoigui
patent: 2004/0057944 (2004-03-01), Galle et al.
patent: 2004/0092449 (2004-05-01), Ekwuribe
patent: 3941324 (1990-11-01), None
patent: 2.129.947 (1972-11-01), None
patent: HEI 11-49699 (1999-02-01), None
patent: WO 98/36734 (1998-08-01), None
van Esch et al., Pharmacological management of pain in chronic pancreatitis. Dig Liver Dis. Jul. 2006;38(7):518-26. Epub Apr. 14, 2006. Review.
Shiratori et al, Clinical evaluation of oral administration of a cholecystokinin-A receptor antagonist (loxiglumide) to patients with acute, painful attacks of chronic pancreatitis: a multicenter dose-response study in Japan. Pancreas. Jul. 2002;25(1):e1-5.
Ochi et al, Clinical evaluation of cholecystokinin-A- receptor antagonist (loxiglumide) for the treatment of acute pancreatitis. A preliminary clinical trial. Study Group of Loxiglumide in Japan. Digestion. 1999;60 Suppl 1:81-5.
“American Gastroenterological Association Medical Position Statement: Treatment of Pain in Chronic Pancreatitis,”Gastroenterology, 115, 763-764 (1998).
Andren-Sandberg, A., “Enzyme Substitution in Pancreatic Disease,”Digestion, 37(1), 35-46 (1987).
Andren-Sandberg, A., “Theory and Practice in the Individualization of Oral Pancreatic Enzyme Administration for Chronic Pancreatitis,”International Journal of Pancreatology, 5, 51-62 (1989).
Apte, M.V., et al. “Chronic Pancreatitis: Complications and Management,”J. Clin. Gastroenterol, 29(3), 225-240 (1999).
Bracale G., et al., “Clinical Study of the Efficacy of and Tolerance to Seaprose S in Inflammatory Venous Disease. Controlled Study Versus Serratio-Peptidase”,Minerva Cardioangiol., 44 (10), 515-524 (1996)—English abstract only from PubMed, www.ncbi.nlm.gov.
Braga, P.C., et al., “Effects of Seaprose on the Rheology of Bronchial Mucus in Patients with Chronic Bronchitis. A Double-Blind Study vs. Placebo,”Int. J. Clin. Pharm. Res., 13(3), 179-185 (1993).
Braga, P.C., et al., “The Influence of Seaprose on Erythromycin Penetration into Bronchial Mucus in Bronchopulmonary Infections,”Drugs Exptl. Clin. Res., 18(3), 105-111 (1992).
Braga, P.C., et al., “In Vitro Rheological Assessment of Mucolytic Activity Induced by Seaprose,”Pharmacological Research, 22(5), 611-617 (1990).
Brown, A., et al., “Does Pancreatic Enzyme Supplementation Reduce Pain in Patients with Chronic Pancreatitis: A Meta-Analysis,”Am. J. Gastroenterology, 92(11), 2032-2035 (1997).
Buscher, H.C.J.L., et al., “Bilateral Thoracoscopic Splanchnicectomy in Patients with Chronic Pancreatitis,”Scand J. Gastroenterol., Supp. 230, 29-34 (1999).
Copenhagen Pancreatitis Study Group, “Copenhagen Pancreatitis Study, An Interim Report from a Prospective Epidemiological Multicentre Study,”Scand. J. Gastroent., 16, 305-312 (1981).
Dindelli, M., et al., “Efficacia clinica e tollerabilita del Seaprose S nel trattamento delle complicanze delle ferite chirurgiche in puerperio”,Minerva Ginecologica, 42, (7-8), 313-315 (1990)—English abstract only.
DiMagno, E. P., et al., “Impaired Cholecystokinin-Pancreozymin Secretion, Intraluminal Dilution, and Maldigestion of Fat in Sprue,”Gastroenterology, 63(1), 25-32 (1972).
Dobrilla, G., “Management of Chronic Pancreatitis,”International Journal of Pancreatology, 5, 17-29 (1989).
Food and Drug Administration, “75-day Premarket Notification for New Dietary Ingredient,” (1998).
Greenberger, N. J., “Enzymatic Therapy in Patients with Chronic Pancreatitis,”Gastroenterology Clinics of North America, 28(3), 687-692 (1999).
Halgreen, H., et al., “Symptomatic Effect of Pancreatic Enzyme Therapy in Patients with Chronic Pancreatitis,”Scand. J. Gastroent., 21, 104-108 (1986).
Isaksson, G., et al., “Pain Reduction by an Oral Pancreatic Enzyme Preparation in Chronic Pancreatitis,”Digestive Diseases and Sciences, 28 (2), 97-102 (1983).
Lankisch, P.G., “Conservative Treatment of Chronic Pancreatitis,”Digestion, 37(1), 47-55 (1987).
Layer, P.H., et al., “Klinik und Klassifikation der akuten Pankreatitis,”Praxis, 392-396—English abstract only.
Lebenthal, E., et al., “Enzyme Therapy for Pancreatic Insufficiency: Present Status and Future Needs,”Pancreas, 9(1), 1-12 (1994).
Liddle, R. A., et al., “Proteins but not Amino Acids, Carbohydrates, or Fats Stimulate Cholecystokinin Secretion in the Rat,”Am. J. Physiol. Gastrointest. Liver Physiol., 251, G243-G248 (1986).
Liddle, R. A., “Regulation of Cholecystokinin Secretion by Intraluminal Releasing Factors,”Am. J. Physiol. Gastrointest. Liver Physiol., 269, G319-G327 (1995).
Liddle, R. A., “Regulation of Cholecystokinin Secretion in Humans,”J. Gastroenterology, 35, 181-187 (2000).
Liddle, R. A., “Cholecystokinin Cells,”Annu. Rev. Physiol., 59, 221-242 (1997).
Liddle, R. A., “On the Measurement of Cholecystokinin,”Clinical Chemistry, 44(5), 903-904 (1998).
Liddle, R. A., “Regulation of Cholecystokinin Synthesis and Secretion in Rat Intestine,”American Institute of Nutrition, 1308S-1314S (1994).
Luisetti, M., et al., “Some Properties of the Alkaline Proteinase from Aspergillus Melleus,”Int. J. Tiss. Reac., 13(4), 187-192 (1991).
Malfertheiner, P., et al., “Effect of Exogenous Pancreatic Enzymes on Gastrointestinal and Pancreatic Hormone Release and Gastrointestinal Motility,”Digestion, 54(2), 15-20 (1993).
Miyasaka, K., et al., “Feedback Regulation by Trypsin: Evidence for Intraluminal CCK-Releasing Peptide,”Am. J. Physiol. Gastrointest. Liver Physiol., 257, G175-G181 (1989).
Moretti, M., et al., “Effects of Seaprose on Sputum Biochemical Components in Chronic Bronchitic Patients: A Double-Blind Study vs Placebo,”Int. J. Clin. Pharm. Res., 13(5), 275-280 (1993).
Mossner, J., “Palliation of Pain in Chronic Pancreatitis,”Acute and Chronic Pancreatitis, 79(4), 861-873 (1999).
Mossner, J., et al., “Treatment of Pain with Pancreatic Extracts in Chronic Pancreatitis: Results of a Prospective Placebo-Controlled Multicenter Trial,”Digestion, 53, 54-66 (1992).
Mossner, J., “Is There a Place for Pancreatic Enzymes in the Treatment of Pain in Chronic Pancreatitis?”Digestion, 54(2), 35-39 (1993).
Niederau, C., et al., “Beneficial Effects of Cholecystokinin-receptor Blockage and Inhibition of Proteolytic Enzyme Activity in Experimental Acute Hemorrhagic Pancreatitis in Mice,”J. Clin. Invest., 78, 1056-1063 (1986).
Okhlobystin, A. V., et al., “Enzyme Preparations in Conservative Treatment of Chronic Pancreatitis,” Tepaneimg id="CUSTOM-CHARACTER-00001" he="3.13mm" wi="7.79mm" file="US07459155-20081202-P00001.TIF" alt="custom character" img-content="character" img-format="tif" ?eckimg id="CUSTOM-CHARACTER-00002" he="3.13mm" wi="3.89mm" file="US07459155-20081202-P00002.TIF" alt="custom character" img-content="character" img-format="tif" ?

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Treating abdominal pain due to pancreatitis with seaprose does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Treating abdominal pain due to pancreatitis with seaprose, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treating abdominal pain due to pancreatitis with seaprose will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4040281

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.