Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-04-18
2006-04-18
Fredman, Jeffrey (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
Reexamination Certificate
active
07029850
ABSTRACT:
The present invention relates to a process for sensing biological or chemical changes in molecular structural shape or mass of molecules attached to the surface of a transverse shear piezoelectric oscillating molecular sensing device driven by a network analyzer. The process comprises the steps of i) exciting the sensor device at a series of predetermined frequencies, ii) collecting data to determine values for the predetermined parameters of series resonance frequency shift (fS), motional resistance (RM), motional inductance (LM), motional capacitance (CM), electrostatic capacitance (Co) and boundary layer slip parameter (α); and iii) determining relative changes in the measured parameters to detect thereby any changes in molecular structural shape or mass at sensing device surface.
REFERENCES:
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{hacek over (C)}avić et al., “Acoustic waves and the real-time study of biochemical macromolecules at the liquid/solid interface”,Faraday Discussions,1997, 107, pp. 159-176.
Ferrante et al., “Molecular slip at the solid-liquid interface of an acoustic-wave sensor”,Journal of Applied Physics,76 (6), Sep. 15, 1994, pp. 3448-3462.
Su et al., “Platinum Anticancer Drug Binding to DNA Detected by Thickness-Shear-Mode Acoustic Wave Sensor”,Analytical Chemistry,vol. 67, No. 5, Mar. 1, 1995, pp. 1010-1013.
Hayward Gordon L.
Thompson Michael
Borden Ladner Gervais LLP
Calamita Heather G.
Fredman Jeffrey
Marsman Kathleen
SencorChem International Corporation
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