Transthoracic intrapulmonary immunization against Actinobacillus

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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4242341, 424825, A61K 39102, A61K 3902

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active

054569141

ABSTRACT:
The invention is directed to a method for immunizing an animal for the production of high levels of IgA antibodies against a lung pathogen. The method comprises administering an antigen by transthoracic injection directly into the lung of the animal, the elicited antibodies having specific activity against the administered antigen and lung pathogen of interest. The invention provides a method of stimulating the production of IgA antibodies at mucosal surfaces of the lungs to increase IgA antibody titers in lung fluids and reduce the severity of the lung disease of interest.

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