Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1993-01-26
1995-10-10
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4242341, 424825, A61K 39102, A61K 3902
Patent
active
054569141
ABSTRACT:
The invention is directed to a method for immunizing an animal for the production of high levels of IgA antibodies against a lung pathogen. The method comprises administering an antigen by transthoracic injection directly into the lung of the animal, the elicited antibodies having specific activity against the administered antigen and lung pathogen of interest. The invention provides a method of stimulating the production of IgA antibodies at mucosal surfaces of the lungs to increase IgA antibody titers in lung fluids and reduce the severity of the lung disease of interest.
REFERENCES:
A. Confer et al., "Immunologic Response to Pasteurella haemolytica and Resistance Against Experimental Bovine Pasteurellosis, Induced by Bacterins in Oil Adjuvants", Am. J. Vet. Res., 48:163 (1987).
Confer et al. Am J. Vet Res 48(2):163-168 1987.
Purdy et al. Am J. Vet Res 52(8):1214-1220 Aug. 1991.
Yoshizawa et al. J. Lab. Clin. Med. 100(1):61-69 Jul. 1882.
Wilke et al. Am. J. Vet Res 41(11):1773-8 Nov. 1980.
Wilke et al. Am. J. Vet Res 40(12):1690-3 Dec. 1979.
Tizard, ed. an Introduction to Vet. Immunol. 1982 see pp. 178-92 Chapter 12.
Unanue et al. ed. Textbook of Immunology 2nd edition 1982 see pp. 5-7.
W. J. C. Bogaerts et al., "Immunization of Mice Against Encephalomyocarditis Virus, Infection and Immunity", 6: 513-517 (1972).
A. Confer et al., "Effect of Prior Natural Exposure to Pasteurella haemolytica on Resistance to Experimental Bovine Pneumonic Pasteurellosis", Am. J. Vet. Res., 45: 2622 (1984).
A. Confer et al., "Serum Antibodies to Pasteurella haemolytica Lipopolysaccharide: Relationship to Experimental Bovine Pneumonic Pasteurellosis", Am. J. Vet. Res., 47: 1134 (1986).
A. Confer et al., "Serum Antibodies to Antigens Derived from a Saline Extract of Pasteurella haemolytica: Correlation with Resistance to Experimental Bovine Pneumonic Pasteurellosis", Vet. Immunol. Immunopath., 10:265 (1985).
A. Confer et al., "Isolation of Pasteurella haemolytica and Correlation with Serum Antibody Response in Clinically Normal Beef Calves", Vet Microbiol., 8:601 (1983).
P. Fedorka-Cray et al., "Efficacy of a Cell Extract from Actinobacillus (Haemophilus) pleuropneumoniae Serotype 1 against Disease in Swine", Infusion and Immunity, 58:358-365 (1990).
M. Gentry et al., "Neutralizing Monoclonal Antibodies to Pasteurella haemolytica Leukotoxin Affinity-Purify the Toxin from Crude Culture Supernatants", Microbial Pathogenesis, 10:411-417 (1991).
J. A. Kasel et al., "Influenza Antibody in Human Respiratory Secretions after Subcutaneous or Respiratory Immunization with Inactivated Virus", Nature, 218:594-595 (1968).
D. S. McVey et al., "Antibodies to Pasteurella haemolytica Somatic Antigens in two Models of the Bovine Respiratory Disease Complex", Am. J. Vet. Res., 50:443-447 (1989).
D. S. McVey et al., "Specificity of Bovine Serum Antibody to Capsular Carbohydrate Antigens from Pasteurella haemolytica", J. Clin. Microbiol., 28:1151-1158 (1990).
D. A. Mosier et al., "Serum IgG and IgM Antibody Response in Cattle to Antigens of Pasteurella haemolytica", Vet. Immunol. Immunopath., 22:53 (1989).
P. Newman et al., "Distribution of Pasteurella haemolytica and Pasteurella multocida in the Bovine Lung Following Vaccination and Challenge Exposure as an Indicator of Lung Resistance", Am. J. Vet. Res., 43:417 (1982).
R. J. Panciera et al., "Bovine Pneumonic Pasteurellosis: Model for Pasteurella haemolytica- and Pasteurella multocida-induced Pneumonia in Cattle", Am. J. Vet. Res., 45:2532 (1984).
R. J. Panciera et al., "Bovine Pneumonic Pasteurellosis: Effect of Vaccination with Live Pasteurella Species", Am. J. Vet. Res., 45:2538 (1984).
F. Payvandi et al., "Monoclonal Antibodies for Coagglutination of Streptococcus suis Type 1", Vet. Microbiol., 20:349-356 (1989).
C. Purdy, "Immune Response to Pulmonary Injection of Pasteurella haemolytica-impregnated Agar Beads Followed by Transthoracic Challenge Exposure in Goats", Am J. Vet. Res., 51: 1629 (1990).
T. Sakata et al., "Experimental Hypersensitivity Pneumonitis in Rabbits Induced by Trichosporon cutaneum: Role of Local Cellular and Humoral Immune Responses", J. Clin. Lab. Immunol., 25:191 (1988).
S. Srikumaran et al., "Quantitation of Bovine Immunoglobulins in Culture Fluids by use of Sandwich Radioimmunoassay with Monoclonal Antibodies", Am. J. Vet. Res., 52:243-246 (1991).
D. Stine et al., "Actinobacillus pleuropneumoniae-induced Thymic Lesions in Mice And Pigs", Respiratory Diseases, Abstract 314 (about 1991).
D. Stine et al., "Actinobacillus pleuropneumoniae-Induced Thymic Lesions in Mice and Pigs", Infection and Immunity, 59:2885-2891 (1991).
E. Stott et al., "Immune and Histopathological Responses in Animals Vaccinated with Recombinant Vaccinia Viruses that Express Individual Geses of Human Respiratory Syncytial Virus", J. Virol., 61:3855 (1987).
D. Van Zaane et al., "Monoclonal Antibodies against Bovine Immunoglobulins and their Use in Isotype-Specific ELISAs for Rotavirus Antibody", J. Immunol. Meth., 72:427-441 (1984).
R. Walker et al., "Study of Bovine Pulmonary Response to Pasteurella haemolytica: Pulmonary Macrophage Response", Am. J. Vet. Res., 41-1008 (1980).
R. Walker et al., "Study of Bovine Pulmonary Response to Pasteurella haemolytica: Specificity of Immunoglobulins Isolated from the Bovine Lung", Am. J. Vet. Res., 41:1015 (1980).
Rhodes Marvin B.
Srikumaran Subramaniam
Stine Douglas L.
Board of Regents of the University of Nebraska
Caputa Anthony C.
Nucker Christine M.
LandOfFree
Transthoracic intrapulmonary immunization against Actinobacillus does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Transthoracic intrapulmonary immunization against Actinobacillus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transthoracic intrapulmonary immunization against Actinobacillus will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2309151