Transporter protein

Details Transporter protein Transporter protein

2008-01-22

2008-01-22

Swartz, Rodney P (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

C424S184100, C424S190100, C424S200100, C424S234100, C424S257100, C435S041000, C435S069100, C435S071100, C435S440000, C435S471000, C435S476000, C530S300000, C530S350000, C536S023100, C536S023700

Reexamination Certificate

active

11276614

ABSTRACT:
A novel protein which has an activity to transport hydantoin compounds is described, as well as a recombinant expressing this transporter protein. FromMicrobacterium liquefaciensstrain AJ3912, a novel gene was discovered to encode a protein which is able to transport hydantoin compounds. A recombinant with an excellent ability to uptake hydantoin compounds is obtained by introducing and expressing the novel gene, called mhp, using gene recombination techniques.

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Sumrada, R., et al., “Allantoin Transport inSaccharomyces cerevisiae,” J. Bacteriol. 1977;131(3):839-847.
Watanabe, K., et al., “Cloning and Sequencing of the Gene Involved in the Conversion of 5-Substituted Hydantoins to the Corresponding L-Amino Acids from the Native Plasmid ofPseudomonassp. Strain NS671,” J. Bacteriol. 1992;174(3):962-969.
Wiese, A., et al., “Organization of gene responsible for the stereospecific conversion of hydantoins to α-amino acids inArthrobacter aurescensDSM 3747,” Arch. Microbiol. 2001;176:187-196.
Wilms, B., et al., “Development of anEscherichia coliwhole cell biocatalyst for the production of L-amino acids,” J. Biotechnol. 2001;86:19-30.
International Search Report for PCT Appl. No. PCT/JP2004/013066 (Dec. 28, 2004).

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