Transporter genes OATP-B,C,D, and E

Details Transporter genes OATP-B,C,D, and E Transporter genes OATP-B,C,D, and E

2006-05-16

2006-05-16

Andres, Janet L. (Department: 1647)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S320100, C435S325000, C530S350000, C536S023500

Reexamination Certificate

active

07045316

ABSTRACT:
Four novel transporter genes were successfully cloned by screening novel transporter genes based on the human OATP transporter gene sequence. These transporters are useful in the development of drugs by taking advantage of the activity of transporting biological substances and various drugs. It was also found that these transporter genes have single nucleotide polymorphisms (SNP). Gene diagnosis based on the polymorphisms (such as SNP) in these transporter genes enables one to judge, for example, the efficacy of a drug therapy.

REFERENCES:
patent: 1 186 672 (2002-03-01), None
patent: 1 186 682 (2002-03-01), None
patent: WO 96/27009 (1996-09-01), None
patent: WO 00/01817 (2000-01-01), None
patent: WO 00/08157 (2000-02-01), None
patent: WO 00/09557 (2000-02-01), None
patent: WO 01/09185 (2000-02-01), None
patent: WO 00/26245 (2000-05-01), None
patent: WO 00/29574 (2000-05-01), None
patent: WO 00/55173 (2000-09-01), None
patent: WO 00/61755 (2000-10-01), None
patent: WO 00/71566 (2000-11-01), None
patent: WO 01/74897 (2001-10-01), None
Bisson, et al, 1993, Crit Rev Biochem Mol Biol, 28: 259-308.
Liang, H., et al (1998) Mol. Cell. Biol. 18(2): 926-935.
Tamai, et al, 2000, Biochem. Biophys. Res. Comm., 273: 251-260.
Abe, et al, 1999, J. Biol. Chem., 274(24): 17159-17163.
Wang et al., 1999, Nuc. Acids Res. 27: 4609-4618.
Kaufman et al, 1999, Blood 94: 3178-3184.
Wigley et al., 1994, Reprod Fert Dev 6: 585-588.
Campbell et al., 1997, Theriology 47(1): 63-72.
Phillips, A., J, 2001, Pharm Pharmacology 53: 1169-1174.
EMBL Accession No. AL117465, Koehrer, et al., 2000.
EMBL Accession No. AI668650, 1999, Strausberg.
EMBL Accession No. AI734250, 1999, Strausberg.
EMBL Accession No. AI052501, 1998, Strausberg.
EMBL Accession No. AW590751, 2000, Strausberg.
EMBL Accession No. AW138790, 1999, Strausberg.
Nagase et al., “Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro” DNA Research, vol. 5, No. 6, 355-364, Dec. 31, 1998.
Nagase et al., Genbank Accession no. AB020687. 094956.
Fei et al., “Expression cloning of a mammalian prot0n-coupled oligopeptide transporter” Nature, vol. 368, 563-566, Apr. 7, 1994.
Tamai, et al., “Molecular identification and Characterization of Novel Members of the Human Organic Anion Transporter (OATP) Family”, Biochemical and Biophysical Research Communications, vol. (273) pp. 251-260 (2000).
Kullak-Ublick et al., “Molecular and Functional characterization of an organic Anion Transporting Polypeptide Cloned from Human Liver” Gastorenterology, vol. 109, No. 4, 1274-1282. Oct., 1995.
Kanai, et al., “Identification and Characterization of a Prostaglandin Transporter”, Science, vol. 268, pp. 866-869 (1995).
Abe, et al., “Molecular Characterization and Tissue Distribution of a New Organic Anion Transporter Subtype (oatp3) That Transports Thyroid Hormones and Taurocholate and Comparison with oatp2*”, The Journal of Biological Chemistry, vol. 273 No. 35, pp. 22395-22401 (1998).
Abe, et al., “Identification of a Novel Gene Family Encoding Human Liver-specific Organic Anion Transporter LST-1*”, The Journal of Biological Chemistry, vol. 274 No. 24, pp. 17159-17163, (1999).
Hsiang, et al., “A Novel Human Hepatic Organic Anion Transporting Polypeptide (OATP2)”, The Journal of Biological Chemistry, vol. 274 No. 52, pp. 37161-37186 (1999).
Tioma, et al., “Polymorphisms inOATP—Identification of Multiple Allelic Variants Associated with Altered Transport Activity Among European-and African-Americans*”, vol. 276 No. 38, pp. 35669-35675, (2001).
Abe et al.,J. Biol. Chem.274(24):17159-17163, 1999.
Hsaing et al.,J. Biol. Chem.274(52):37161-37168, 1999.
Konig et al.,Am. J. Physiol. Gastrointest. Liver Physiol.278(1):G156-G164, 2000.
Konig et al.,The Journal of Biological Chemistry275(30):23161-23168, 2000.
Tamai et al.,Biochem. Biophys. Res. Commun.273(1):251-260, 2000.
EMBL Accession No. Q9Y6L6, Oct. 16, 2001.
Hsiang et al., EMBL Accession No. AF205071, Dec. 28, 1999.
Koenig et al., EMBL Accession No. A132573, Dec. 10, 1999,
Nezu et al., EMBL Accession No. AB026257, Jun. 8, 1999.
Abe et al., EMBL Accession No. AF060500, Jun. 15, 1999.

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