Transport protein which effects the transport of cationic xenobi

Details Transport protein which effects the transport of cationic xenobi Transport protein which effects the transport of cationic xenobi

1995-07-12

2000-05-16

Kemmerer, Elizabeth

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

435 721, 435 691, 435 703, 435325, 536 235, 536 2431, C07K 14435, C12N 510, C12N 1512

Patent

active

060636238

ABSTRACT:
A transport protein has been cloned which is present in liver epithelial cells and kidney epithelial cells and in intestinal cells and is responsible for transporting cationic pharmaceuticals and/or xenobiotics. This transport protein has been described more specifically by its DNA and amino acid sequences, and various uses are disclosed which are, in particular, of great importance for developing novel medicaments.

REFERENCES:
Simonson et al. Molecular cloning and characterization of a novel liver-specific transport protein. Journal of Cell Science. vol. 107, pp. 1065-1072, Apr. 1994.
Boerner et al. Polarity of neutral amino acid transport and characterization of a broad specificity transport activity in a kidney epithelial cell line, MDCK. The Journal of Biological Chemistry. vol. 261, No. 30, pp. 13957-13962, Oct. 25, 1986.
Grundemann et al. Drug excretion mediated by a new prototype of polyspecific transporter. Nature. vol. 372, pp. 549-552, Dec. 8, 1994.
Bowie et al. Science 247:1306-1310, 1990.
Wells. Biochemistry 29:8509-8517, 1990.
Ngo et al. The Protein Folding Problem and Tertiary Structure Prediction, Merz et al., eds., Birkhauser, Boston, pp. 492-495, 1994.
Schulz et al. Principles of Protein Structure, Springer-Verlag, New York, pp. 14-16, 1979.
Georges et al. Macromolecular Sequencing and Synthesis: Selected Methods and Applications, Schlesinger, ed., Alan R. Liss, Inc., NY, pp. 127-149, 1988.
Watson et al. Molecular Biology of the Gene, Benjamin/Cummings Publishing Co., Inc., Menlo Park, p. 313, 1987.

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