Transport protein gene from the Huntington's disease region

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 691, 4352402, 4353201, 530350, 536 221, 536 231, 536 234, 536 235, C12Q 168, C12P 2106, C07H 1900, C07H 2100

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055388442

ABSTRACT:
The present invention relates, in general, to a novel transport protein, IT10C3. In particular, the present invention relates to nucleic acid molecules coding for IT10C3; IT10C3 polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antisense IT10C3 nucleic acid constructs; antibodies having binding affinity to an IT10C3 polypeptide; hybridomas containing the antibodies; nucleic acid probes for the detection of IT10C3 nucleic acid; a method of detecting IT10C3 nucleic acid or polypeptide in a sample; and kits containing nucleic acid probes or antibodies.

REFERENCES:
Daly, C. B., "Genetic cause is identified for Huntington's disease", The Washington Post, Mar. 24, 1993.
Goldberg, Y. P. et al., "Identification of an Alu retrotransposition event in close proximity to a strong candidate gene for Huntington's disease", Nature 362:270-373 (Mar. 25, 1993).
Goodfellow, P. N., "Planting alfalfa and cloning the Huntington's disease gene", Cell 72:817-818 (Mar. 26, 1993).
Little, P., "The end of the beginning", Nature 362:408-409 (Apr. 1, 1993).
MacDonald, M. E. et al., "A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes", Cell 72:971-983 (Mar. 26, 1993).
Morell, V., "Huntington's gene finally found", Science 260:28-30 (Apr. 2, 1993).
Richards, R. I. et al., "Evidence of founder chromosomes in fragile X syndrome", Nature Genetics 1:257-260 (Jul. 1992).
Altschul, S. F. et al., "Basic local alignment search tool", J. Mol. Biol. 215:403-410 (1990).
Ambrose, C. et al., "A novel G protein-coupled receptor kinase cloned from 4p16.3", Hum. Mol. Genet. 1(9):697-703 (1992).
Bates, G. P. et al., "Define physical limits of the Huntington disease gene candidate region", Am. J. Hum. Genet. 49:7-16 (1991).
Bates, G. P. et al., "Characterization of a yeast artificial chromosome contig spanning the Huntington's disease gene candidate region", Nature Genet. 1:180-187 (Jun. 1992).
Buckler, A. J. et al., "Exon amplification: a strategy to isolate mammalian genes based on RNA splicing", Proc. Natl. Acad. Sci. USA 88:4005-4009 (May 1991).
Gusella, J. F., "Chapter 3--Huntington's disease", Adv. Hum. Genet. 20:125-151 (1991).
Levy, S. B. "Tetracycline resistance determinants are widespread", Am. Soc. Microbiol. News 54(8):418-421 (1988).
Lin, C. S. et al., "New DNA markers in the Huntington's disease gene candidate region", Somat. Cell Mol. Genet. 17(5):481-488 (1991).
Liu, Y. et al., "A cDNA that suppresses MPP.sup.+ toxicity encodes a vesicular amine transporter", Cell 70:539-551 (Aug. 21, 1992).
MacDonald, M. E. et al., "The Huntington's disease candidate region exhibits many different haplotypes", Nature Genet. 1:99-103 (May 1992).
MacDonald, M. E. et al., "A somatic cell hybrid panel for localizing DNA segments near the Huntington's disease gene", Genomics 1:29-34 (1987).
MacDonald, M. E. et al., "Recombination events suggest potential sites for the Huntington's disease gene", Neuron 3:183-190 (Aug. 1989).
Marger, M. D. and Saier, M. H. Jr., "A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport", TIBS 18:13-20 (Jan. 1993).
Martin, J. B. and Gusella, J. F., "Huntington's disease: pathogenesis and management", N. Engl. J. Med. 315(20):1267-1276 (Nov. 13, 1986).
McClatchey, A. I. et al., "The genomic structure of the human skeletal muscle sodium channel gene", Hum. Mol. Genet. 1(7):521-527 (1992).
Smith, B. et al., "Isolation of DNA markers in the direction of the Huntington disease gene from the G8 locus", Am. J. Hum. Genet. 42:335-344 (1988).
Snell, R. G. et al., "A recombination event that redefines the Huntington disease region", Am. J. Hum. Genet. 51:357-362 (1992).
Taylor, S. A. M. et al., "Cloning of the .alpha.-adducin gene from the Huntington's disease candidate region of chromosome 4 by exon amplification", Nature Genet. 2:223-227 (Nov. 1992).
Yamaguchi, A. et al., "Stoichiometry of metal-tetracycline/H.sup.+ antiport mediated by transpson Tn10-encoded tetracycline resistance protein in Escherichia coli", FEBS Lett. 282(2):415-418 (May 1991).

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