Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Reexamination Certificate
2006-07-19
2010-10-05
Swartz, Rodney P. (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
C424S184100, C424S185100, C424S192100, C424S234100, C530S300000, C530S350000, C536S023100, C536S023700
Reexamination Certificate
active
07807183
ABSTRACT:
The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived fromNeisseriaouter membrane proteins, such as Laz. The invention also provides synthetic transit peptides comprised of the pentapeptide AAEAP (SEQ ID NO: 25). The invention further discloses methods for treating cancer, and specifically brain cancer, as well as other brain-related conditions. Further, the invention provides methods of imaging and diagnosing cancer, particularly brain cancer.
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Chakrabarty Ananda M.
Das Gupta Tapas K.
Fialho Arsenio M.
Hong Chang Soo
Yamada Tohru
Sheppard Mullin Richter & Hampton LLP
Swartz Rodney P.
The Board of Trustees of the University of Illinois
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