Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1997-05-28
2000-08-29
Degen, Nancy
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424 851, 424 937, 435325, 435366, 435371, 435373, 435374, 435395, A01N 6300, A61K 3818, C12N 502, C12N 506
Patent
active
061104590
ABSTRACT:
A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal myoblasts. The grafts are especially useful in treating scar tissue on the heart. Also provided is a method of isolating and culturing cardiomyocytes for use in such grafts.
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patent: 5580779 (1996-12-01), Smith et al.
patent: 5602301 (1997-02-01), Field
Loer et al., "Transplantation of Fetal Myocardial Tissue Into the Infarcted Myocardium of Rat; A Potential Method for Repair of Infarcted Myocardium?" Cell Transplants 94:(Supplement II) II-332-II-336 (1996).
Murry et al., "Skeletal Myoblast Transplantation for Repair of Myocardial Necrosis" J. Clin. Invest. 98:2512-2523 (1996).
Chiu et al. Cellular Cardiomyoplasty: Mycardial Regeneration With Satellite Cell Implantation. Ann. Thorac. Surg. 60: 12-18, 1995.
Li et al.; Cardiomyocyte Transplantation Improves Heart Function; 1996 by the Society of Thoracic Surgeons; pp. 654-661.
Li et al.; Method of Culturing Cardiomyocytes from Human Pediatric Ventricular Myocardium; 1992 J. Tiss. Cult. Meth.; pp. 93-100.
Li et al.; Human Pediatric and Adult Ventricular Cardiomyocytes in Culture: Assessment of Phenotypic Changes with Passaging; Feb. 20, 1996 Cardiovascular Research; pp. 1-12.
Li Ren-Ke
Mickle Donald A. G.
Weisel Richard D.
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