Transparent non-fibrilized collagen material by ultracentrifugat

Details Transparent non-fibrilized collagen material by ultracentrifugat Transparent non-fibrilized collagen material by ultracentrifugat

1982-09-30

1985-03-19

Bleutge, John C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2041601, 20415914, 128DIG8, 128 1R, 264 14, 264 26, 264 27, 3 13, 351159, C07G 700, A61B 1900, A61F 116

Patent

active

045058555

ABSTRACT:
A transparent native, non-fibrilized collagen material is described having an absorbence at a wavelength of 900 nm of less than 5% in a sample 5 mm thick. This collagen material is useful for a prosthetic replacement of the cornea because of the high transparency and because it is a native material, and thus less susceptible to immunogenic responses. A method for forming the native, non-fibrilized, highly transparent collagen material comprises ultracentrifuging a purified solution of native collagen to form a pellet of transparent collagen material, and fixing the pellet of collagen material to form a rigid, leather-like material. The collagen material can also be used for prosthetic replacement of other bodily tissues, such as nucleus pulposus, cartilage, and vitreous body.

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Dunn, et al., Science 157:1329-1330 (1967).
Dunn, et al., Opthalmic Surgery 2(1):9-11.
Dunn, et al., "Collagen-Derived Membrane: Corneal Implantation," Biomaterials (Plenum Press, N.Y., 1969), 195-199.

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