Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Patent
1993-04-16
1996-01-09
Wityshyn, Michael G.
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
424 851, 424 852, 424 854, 514 3, 514 4, 514 12, 514 21, A61K 3821, A61K 3828, A61K 3829
Patent
active
054827060
ABSTRACT:
A transmucosal therapeutic composition comprising a physiologically active peptide or protein and a cytidine nucleotide derivative is described. The above composition results in a satisfactory transmucosal absorption of physiologically active peptides or proteins which are otherwise hardly absorbed from the mucosa. Since it allows self-administration to the mucosa, such as the nasal, vaginal or digestive tract mucosa, in lieu of injection which causes pain, the invention is of great utility as a pharmaceutical dosage form for physiologically active peptides or proteins which must be administered over a protracted time.
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patent: 4386077 (1983-05-01), Borgo
patent: 4572832 (1986-02-01), Kigasawa et al.
patent: 4789666 (1988-12-01), Gennari
patent: 4900730 (1990-02-01), Miyauchi
patent: 5179079 (1993-01-01), Hansen et al.
Illum, Lisbeth, "The nasal delivery of peptides and proteins", TIBTECH, vol. 9 Aug. 1991, pp. 284-289.
Igari Yasutaka
Taketomi Shigehisa
Yamada Minoru
Conlin David G.
Neuner George W.
Sayala C.
Takeda Chemical Industries Ltd.
Wityshyn Michael G.
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