Transmucosal therapeutic composition

Drug – bio-affecting and body treating compositions – Lymphokine – Interferon

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424 851, 424 852, 424 854, 514 3, 514 4, 514 12, 514 21, A61K 3821, A61K 3828, A61K 3829

Patent

active

054827060

ABSTRACT:
A transmucosal therapeutic composition comprising a physiologically active peptide or protein and a cytidine nucleotide derivative is described. The above composition results in a satisfactory transmucosal absorption of physiologically active peptides or proteins which are otherwise hardly absorbed from the mucosa. Since it allows self-administration to the mucosa, such as the nasal, vaginal or digestive tract mucosa, in lieu of injection which causes pain, the invention is of great utility as a pharmaceutical dosage form for physiologically active peptides or proteins which must be administered over a protracted time.

REFERENCES:
patent: 4059692 (1977-11-01), Takahashi et al.
patent: 4386077 (1983-05-01), Borgo
patent: 4572832 (1986-02-01), Kigasawa et al.
patent: 4789666 (1988-12-01), Gennari
patent: 4900730 (1990-02-01), Miyauchi
patent: 5179079 (1993-01-01), Hansen et al.
Illum, Lisbeth, "The nasal delivery of peptides and proteins", TIBTECH, vol. 9 Aug. 1991, pp. 284-289.

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