Transmucosal therapeutic composition

Details Transmucosal therapeutic composition Transmucosal therapeutic composition

1995-09-12

1998-03-10

Sayala, Chhaya D.

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

424 851, 424 852, 424 854, 514 3, 514 4, 514 12, 514 21, A61K 3821, A61K 3828, A61K 3829

Patent

active

057258520

ABSTRACT:
A transmucosal therapeutic composition comprising a physiologically active peptide or protein and a cytidine nucleotide derivative was produced. The above composition results in a satisfactory transmucosal absorption of physiologically active peptides or proteins which are otherwise hardly absorbed from the mucosa. Since it allows self-administration to the mucosa, such as the nasal, vaginal or digestive tract mucosa, in lieu of injection which causes pain, the invention is of great utility as a pharmaceutical dosage form for physiologically active peptides or proteins which must be administered over a protracted time.

REFERENCES:
patent: 4059692 (1977-11-01), Takahashi et al.
patent: 4179079 (1979-12-01), Hansen et al.
patent: 4386077 (1983-05-01), Borgo
patent: 4572832 (1986-02-01), Kigasawa et al.
patent: 4789666 (1988-12-01), Gennari
patent: 4900730 (1990-02-01), Miyauchi
patent: 5482706 (1996-01-01), Igawi et al.
Illum. Lisbeth, "The nasal delivery of peptides and proteins", TIBTECH, Vol. 9, Aug. 1991, pp. 284-289.

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